New Therapeutic Targets for Drug Design Against Trypanosoma cruzi, Advances and Perspectives

Title: New Therapeutic Targets for Drug Design Against Trypanosoma cruzi, Advances and Perspectives

Volume: 16 Issue: 25

Author(s): Gildardo Rivera, Virgilio Bocanegra-Garcia, Cynthia Ordaz-Pichardo, Benjamin Nogueda-Torres and Antonio Monge

Affiliation:

Keywords: Chagas disease, Trypanosoma cruzi, therapeutic targets, drug design

Abstract: Chagas disease is one of the most important parasitic diseases in Latin America, affecting16 to 18 million people. Nifurtimox and Benznidazol are drugs that are commonly used in its treatment; however, these drugs produce several adverse reactions and are not effective in the chronic phase of the disease. Therefore, the design, synthesis, and biological evaluation of new compounds with potential activity against Trypanozoma cruzi are of great importance. We review six proteins involved in the biochemical metabolism of Trypanosoma cruzi that have recently been studied as potential targets for designing new drugs for Chagas disease. These are farnesyl pyrophosphate synthase, trans-sialidase, cruzain cystein protease, trypanothione reductase, glucose 6-phosphate-dehydrogenase, glyceraldehyde 3-phosphatedehydrogenase, and α-hydroxy acid dehydrogenase. We also review the advances of compounds recently designed based on structure-activity, and the perspectives of new compounds that inhibit these therapeutic targets.

Cite this article as:

Rivera Gildardo, Bocanegra-Garcia Virgilio, Ordaz-Pichardo Cynthia, Nogueda-Torres Benjamin and Monge Antonio, New Therapeutic Targets for Drug Design Against Trypanosoma cruzi, Advances and Perspectives, Current Medicinal Chemistry 2009; 16(25) . https://dx.doi.org/10.2174/092986709788803303