Oral Administration of Hydrogen-rich Water: Biomedical Activities, Potential Mechanisms, and Clinical Applications

Title:Oral Administration of Hydrogen-rich Water: Biomedical Activities, Potential Mechanisms, and Clinical Applications

Volume: 31

Author(s): Fanxianzi Meng, Zhichao Liu, Shucun Qin and Boyan Liu*

Affiliation:

• Shandong Provincial Key Medical and Health Laboratory of Hydrogen Biomedical Research & Key Laboratory of Major Diseases and Hydrogen Medical Translational Applications in Universities of Shandong Province, Taishan Institute for Hydrogen Biomedical Research, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China

Keywords: Hydrogen-rich water, molecular hydrogen, reactive oxygen species, oxidative stress, inflammation, clinical trials

Abstract: Molecular hydrogen (H2) is considered a biological antioxidant. Hydrogen-rich Water (HRW) is regular water that contains dissolved H2 and has become more widely used in recent years. This review summarizes the basic research and clinical applications of HRW consumption to support its use for daily health and clinical treatment. The biological effects of HRW include reducing oxidative stress, exerting antiinflammatory effects, regulating glucose and lipid metabolism, protecting mitochondrial function, and regulating apoptosis. Hypotheses about the mechanisms of H2 include the direct scavenging of toxic free radicals, the Fe-porphyrin biosensor hypothesis, the effect of H2 on biological enzymes, the lipoprotein regulation of H2, and H2 acting on the intestinal barrier. Clinically, HRW has been used for adjuvant treatment, disease prevention, and quality of life improvement. In the future, more in-depth studies and large-scale clinical trials are needed.

Cite this article as:

Meng Fanxianzi, Liu Zhichao, Qin Shucun and Liu Boyan*, Oral Administration of Hydrogen-rich Water: Biomedical Activities, Potential Mechanisms, and Clinical Applications, Current Pharmaceutical Design 2025; 31 () . https://dx.doi.org/10.2174/0113816128330516241121150719