Generic placeholder image

Current Hypertension Reviews

Editor-in-Chief

ISSN (Print): 1573-4021
ISSN (Online): 1875-6506

Review Article

Gestational Hypertension: A Contemporary Review of Epidemiology, Pathophysiology, and Therapeutic Approaches

Author(s): Sunita*, Rahul Kaushik, Praveen Kumar Gaur and Krishan Kumar Verma

Volume 20, Issue 3, 2024

Published on: 26 November, 2024

Page: [117 - 126] Pages: 10

DOI: 10.2174/0115734021312990241115045601

Price: $65

Abstract

Gestational hypertension and preeclampsia are frequently encountered conditions in pregnancy, often occurring around the time of delivery. Mild cases of these conditions in the near term typically result in few complications for both the mother and the newborn. However, women diagnosed with gestational hypertension or preeclampsia need careful monitoring of both maternal and fetal well-being throughout pregnancy, and those with severe symptoms should receive hospital- based management. Preeclampsia is associated with endothelial dysfunction in the mother, prolonged immunological activation, fetal development limitation, hypertension with or without proteinuria, and endothelial dysfunction after week twenty of pregnancy. Pregnancy-related hypertension raises concerns, although the main issues are related to the progression of the condition to pre-eclampsia or eclampsia and HELLP syndrome. In this review, the cross-sectional study of gestational hypertension is evaluated, and the treatment approaches are highlighted.

Keywords: Gestational hypertension, preeclampsia, pregnancy induced hypertension, hemolysis, elevated liver enzymes and low platelets, proteinuria.

Next »
Graphical Abstract
[1]
Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ESC guidelines for the management of arterial hypertension. Arterial Hypertens 2013; 17(2): 69-168.
[2]
Whelton PK, Carey RM, Aronow WS, et al. Force on clinical practice guidelines. Hypertension 2018; 71(6): 1269-324.
[http://dx.doi.org/10.1161/HYP.0000000000000066] [PMID: 29133354]
[3]
Carey RM, Muntner P, Bosworth HB, Whelton PK. Prevention and control of hypertension: JACC health promotion series. J Am Coll Cardiol 2018; 72(11): 1278-93.
[http://dx.doi.org/10.1016/j.jacc.2018.07.008] [PMID: 30190007]
[4]
V RAGHU. Prevalence and patterns of cardiovascular risk factors in young hypertensive patients. DJCM 2024; 6(3): 2.
[5]
Njuguna J. Planned delivery at 37 weeks gestation versus expectant management for non-severe chronic hypertension, a systematic review. A dissertation submitted in part fulfillment of the requirements for the degree of Master of Medicine In Obstetrics and Gynecology 2021.
[6]
Mennitto S. Associations between mindfulness, psychological health and aspects of cardiovascular function in pregnancy. Canada: McGill University 2022.
[7]
Wu XY, Li ZL, Wu CY, et al. Endocrine traits of polycystic ovary syndrome in prenatally androgenized female Sprague-Dawley rats. Endocr J 2010; 57(3): 201-9.
[http://dx.doi.org/10.1507/endocrj.K09E-205] [PMID: 20057162]
[8]
Lei J, Zhao M, Li L, Ji B, Xu T, Sun M, et al. Research progress of placental vascular pathophysiological changes in pregnancy-induced hypertension and gestational diabetes mellitus. S.A.: Frontiers Media 2022; Vol. 13.
[9]
Hamad RN, Zangana JM. Comparing non-stress test versus Umbilical Artery doppler velocimetry among Aample of high-risk pregnant women in Erbil city. BJMS 2023.
[http://dx.doi.org/10.3329/bjms.v22i20.66301]
[10]
Ado MS, Suwaid MA, Dambatta AH, Lawal Y. Sonographic estimation of gestational age using transverse cerebellar diameter among late trimester pregnancies in Kano, Northwest Nigeria. West Afr J Radiol 2023; 30(1): 20-5.
[http://dx.doi.org/10.4103/wajr.wajr_2_24]
[11]
Gudeta TA, Regassa TM. Pregnancy induced hypertension and associated factors among women attending delivery service at mizan-tepi university teaching hospital, tepi general hospital and gebretsadik shawo hospital, southwest, Ethiopia. Ethiop J Health Sci 2019; 29(1): 831-40.
[PMID: 30700950]
[12]
Braunthal S, Brateanu A. Hypertension in pregnancy: Pathophysiology and treatment. SAGE Open Med 2019; 7: 2050312119843700.
[http://dx.doi.org/10.1177/2050312119843700] [PMID: 31007914]
[13]
Cesne AL, Judson I, Maki R, et al. Trabectedin is a feasible treatment for soft tissue sarcoma patients regardless of patient age: A retrospective pooled analysis of five phase II trials. Br J Cancer 2013; 109(7): 1717-24.
[http://dx.doi.org/10.1038/bjc.2013.524] [PMID: 24022187]
[14]
Padda J, Khalid K, Colaco LB, et al. Efficacy of magnesium sulfate on maternal mortality in eclampsia. Cureus 2021; 13(8): e17322.
[http://dx.doi.org/10.7759/cureus.17322] [PMID: 34567870]
[15]
Tadic M, Cuspidi C, Suzic Lazic J, et al. Blood pressure variability correlates with right ventricular strain in women with gestational hypertension and preeclampsia. J Hum Hypertens 2022; 36(9): 826-32.
[http://dx.doi.org/10.1038/s41371-021-00580-x] [PMID: 34272473]
[16]
Hamilton BE, Martin JA, Osterman MJ, Rossen LM. Births: Provisional data for 2018 2018. Available from: https://www.cdc.gov/nchs/data/vsrr/vsrr-007-508.pdf
[17]
Goldstein RF, Abell SK, Ranasinha S, et al. Association of gestational weight gain with maternal and infant outcomes: A systematic review and meta-analysis. JAMA 2017; 317(21): 2207-25.
[http://dx.doi.org/10.1001/jama.2017.3635] [PMID: 28586887]
[18]
Voerman E, Santos S, Inskip H, et al. Association of gestational weight gain with adverse maternal and infant outcomes. JAMA 2019; 321(17): 1702-15.
[http://dx.doi.org/10.1001/jama.2019.3820] [PMID: 31063572]
[19]
Hales CM, Fryar CD, Carroll MD, Freedman DS, Ogden CL. Trends in obesity and severe obesity prevalence in US youth and adults by sex and age, 2007-2008 to 2015-2016. JAMA 2018; 319(16): 1723-5.
[http://dx.doi.org/10.1001/jama.2018.3060] [PMID: 29570750]
[20]
Kahan S, Manson JE. Obesity treatment, beyond the guidelines: Practical suggestions for clinical practice. JAMA 2019; 321(14): 1349-50.
[http://dx.doi.org/10.1001/jama.2019.2352] [PMID: 30896727]
[21]
Curry SJ, Krist AH, Owens DK, et al. Behavioral weight loss interventions to prevent obesity-related morbidity and mortality in adults: US Preventive Services Task Force recommendation statement. JAMA 2018; 320(11): 1163-71.
[http://dx.doi.org/10.1001/jama.2018.13022] [PMID: 30326502]
[22]
Sibai BM. Hypertension in pregnancy. Obstet Gynecol Clin North Am 1992; 19(4): 615-32.
[http://dx.doi.org/10.1016/S0889-8545(21)00610-0] [PMID: 1484651]
[23]
Pannu HK, Oliphant M. The subperitoneal space and peritoneal cavity: Basic concepts. Abdom Imaging 2015; 40(7): 2710-22.
[http://dx.doi.org/10.1007/s00261-015-0429-5] [PMID: 26006061]
[24]
Kalra A, Wehrle CJ, Tuma F. Anatomy, abdomen and pelvis, peritoneum. StatPearls publishing 2023.
[25]
Salmani D, Purushothaman S, Somashekara S, et al. Study of structural changes in placenta in pregnancy-induced hypertension. J Nat Sci Biol Med 2014; 5(2): 352-5.
[http://dx.doi.org/10.4103/0976-9668.136182] [PMID: 25097413]
[26]
Jaiman S, Romero R, Pacora P, et al. Disorders of placental villous maturation in fetal death. J Perinat Med 2020; 0(0): 345-68.
[http://dx.doi.org/10.1515/jpm-2020-0030] [PMID: 32238609]
[27]
Christians JK, Grynspan D. Placental villous hypermaturation is associated with improved neonatal outcomes. Placenta 2019; 76: 1-5.
[http://dx.doi.org/10.1016/j.placenta.2019.01.012] [PMID: 30803708]
[28]
Salmani J, Asghar S, Lv H, Zhou J. Aqueous solubility and degradation kinetics of the phytochemical anticancer thymoquinone; probing the effects of solvents, pH and light. Molecules 2014; 19(5): 5925-39.
[http://dx.doi.org/10.3390/molecules19055925] [PMID: 24815311]
[29]
Agrawal AF, Wang AD. Increased transmission of mutations by low-condition females: Evidence for condition-dependent DNA repair. PLoS Biol 2008; 6(2): e30.
[http://dx.doi.org/10.1371/journal.pbio.0060030] [PMID: 18271627]
[30]
VanWijk M, Kublickiene K, Boer K, VanBavel E. Vascular function in preeclampsia. Cardiovasc Res 2000; 47(1): 38-48.
[http://dx.doi.org/10.1016/S0008-6363(00)00087-0] [PMID: 10869528]
[31]
Losada A, Hirano M, Hirano T. Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis. Genes Dev 2002; 16(23): 3004-16.
[http://dx.doi.org/10.1101/gad.249202] [PMID: 12464631]
[32]
Herse F, Dechend R, Harsem NK, et al. Dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsia. Hypertension 2007; 49(3): 604-11.
[http://dx.doi.org/10.1161/01.HYP.0000257797.49289.71] [PMID: 17261642]
[33]
Furuya RS, Cesaroni R, Takahashi S, Codella C, Momose M, Beltrán MT. Candidate rotating toroids around high-mass (proto) stars. Astrophys J 2008; 673(1): 363-81.
[http://dx.doi.org/10.1086/523834]
[34]
Furuya T, Kamlet AS, Ritter T. Catalysis for fluorination and trifluoromethylation. Nature 2011; 473(7348): 470-7.
[http://dx.doi.org/10.1038/nature10108] [PMID: 21614074]
[35]
Khong TY. Placental vascular development and neonatal outcome Semin Neonatol 2004; 9(4): 255-63.
[http://dx.doi.org/10.1016/j.siny.2003.11.010]
[36]
Lian R, Zhu BS, Zeng X. An update review of the pathogenesis hypothesis in preeclampsia. Clin Exp Obstet Gynecol 2022; 49(8): 170.
[http://dx.doi.org/10.31083/j.ceog4908170]
[37]
Harmon AC, Cornelius DC, Amaral LM, et al. The role of inflammation in the pathology of preeclampsia. Clin Sci (Lond) 2016; 130(6): 409-19.
[http://dx.doi.org/10.1042/CS20150702] [PMID: 26846579]
[38]
Jung E, Romero R, Yeo L, et al. The etiology of preeclampsia. Am J Obstet Gynecol 2022; 226(2): S844-66.
[http://dx.doi.org/10.1016/j.ajog.2021.11.1356] [PMID: 35177222]
[39]
Cornelius DC. Preeclampsia: From inflammation to immunoregulation Clin Med Insights Blood Disord 2018; 11: 1179545X17752325.
[http://dx.doi.org/10.1177/1179545X17752325]
[40]
Chang KJ, Seow KM, Chen KH. Preeclampsia: Recent advances in predicting, preventing, and managing the maternal and fetal life-threatening condition. Int J Environ Res Public Health 2023; 20(4): 2994.
[http://dx.doi.org/10.3390/ijerph20042994] [PMID: 36833689]
[41]
Longo SA, Dola CP, Pridjian G. Preeclampsia and eclampsia revisited. South Med J 2003; 96(9): 891-9.
[http://dx.doi.org/10.1097/01.SMJ.0000084385.85123.08] [PMID: 14513987]
[42]
Ożarowski M, Mikołajczak PŁ, Kujawski R, et al. Pharmacological effect of quercetin in hypertension and its potential application in pregnancy-induced hypertension: Review of in vitro, in vivo, and clinical studies. Evid Based Complement Alternat Med 2018; 2018(1): 7421489.
[http://dx.doi.org/10.1155/2018/7421489] [PMID: 30622610]
[43]
Bharadwaj SK, Vishnu Bhat B, Vickneswaran V, Adhisivam B, Bobby Z, Habeebullah S. Oxidative stress, antioxidant status and neurodevelopmental outcome in neonates born to pre-eclamptic mothers. Indian J Pediatr 2018; 85(5): 351-7.
[http://dx.doi.org/10.1007/s12098-017-2560-5] [PMID: 29264827]
[44]
Savitz DA, Danilack VA, Engel SM, Elston B, Lipkind HS. Descriptive epidemiology of chronic hypertension, gestational hypertension, and preeclampsia in New York State, 1995-2004. Matern Child Health J 2014; 18(4): 829-38.
[http://dx.doi.org/10.1007/s10995-013-1307-9] [PMID: 23793484]
[45]
Schneider S, Freerksen N, Maul H, Roehrig S, Fischer B, Hoeft B. Risk groups and maternal-neonatal complications of preeclampsia – Current results from the national German Perinatal Quality Registry. J Perinat Med 2011; 39(3): 257-65.
[http://dx.doi.org/10.1515/jpm.2011.010] [PMID: 21309631]
[46]
Klungsøyr K, Morken NH, Irgens L, Vollset SE, Skjærven R. Secular trends in the epidemiology of pre-eclampsia throughout 40 years in Norway: Prevalence, risk factors and perinatal survival. Paediatr Perinat Epidemiol 2012; 26(3): 190-8.
[http://dx.doi.org/10.1111/j.1365-3016.2012.01260.x] [PMID: 22471678]
[47]
Timpka S, Markovitz A, Schyman T, et al. Midlife development of type 2 diabetes and hypertension in women by history of hypertensive disorders of pregnancy. Cardiovasc Diabetol 2018; 17(1): 124.
[http://dx.doi.org/10.1186/s12933-018-0764-2] [PMID: 30200989]
[48]
Catov JM, Countouris M, Hauspurg A. Hypertensive disorders of pregnancy and CVD prediction: Accounting for risk accrual during the reproductive years J Am Coll Cardiol 2018; 72(11): 1264-6.
[49]
Razzak R, Shivkumar PV. Early prediction of hypertensive diseases of pregnancy by using combined screening methods in a rural population. Cureus 2023; 15(12): e50624.
[http://dx.doi.org/10.7759/cureus.50624] [PMID: 38226112]
[50]
Radparvar AA, Vani K, Fiori K, et al. Hypertensive disorders of pregnancy: Innovative management strategies JACC Adv 2024; 3(3): 100864.
[51]
Yang YY, Fang YH, Wang X, Zhang Y, Liu XJ, Yin ZZ. A retrospective cohort study of risk factors and pregnancy outcomes in 14,014 Chinese pregnant women Medicine (Baltimore) 2018; 97(33): e11748.
[52]
Noronha JA, Bhaduri A, Bhat HV, Kamath A. Maternal risk factors and anaemia in pregnancy: A prospective retrospective cohort study. J Obstet Gynaecol 2010; 30(2): 132-6.
[http://dx.doi.org/10.3109/01443610903267457] [PMID: 20143970]
[53]
Roberts JM, Pearson G, Cutler J, Lindheimer M. Summary of the NHLBI working group on research on hypertension during pregnancy Hypertens Pregnancy 2003; 22(2): 109-27.
[54]
Koual M, Abbou H, Carbonnel M, Picone O, Ayoubi JM. Short-term outcome of patients with preeclampsia. Vasc Health Risk Manag 2013; 9: 143-8.
[PMID: 23610524]
[55]
Coghill AE, Hansen S, Littman AJ. Risk factors for eclampsia: A population-based study in Washington State, 1987–2007. Am J Obstet Gynecol 2011; 205(6): 553.e1-7.
[http://dx.doi.org/10.1016/j.ajog.2011.06.079] [PMID: 21855842]
[56]
Anderson NH, Sadler LC, Stewart AW, Fyfe EM, McCowan LME. Ethnicity, body mass index and risk of pre-eclampsia in a multiethnic N ew Z ealand population. Aust N Z J Obstet Gynaecol 2012; 52(6): 552-8.
[http://dx.doi.org/10.1111/j.1479-828X.2012.01475.x] [PMID: 23020751]
[57]
Bartsch E, Medcalf KE, Park AL, Ray JG. Clinical risk factors for pre-eclampsia determined in early pregnancy: Systematic review and meta-analysis of large cohort studies. BMJ 2016; 353: i1753.
[http://dx.doi.org/10.1136/bmj.i1753] [PMID: 27094586]
[58]
Bener A, Saleh NM. The impact of socio-economic, lifestyle habits, and obesity in developing of pregnancy-induced hypertension in fast-growing country: Global comparisons. Clin Exp Obstet Gynecol 2013; 40(1): 52-7.
[PMID: 23724507]
[59]
Lučovnik M, Tul N, Verdenik I, Novak Ž, Blickstein I. Risk factors for preeclampsia in twin pregnancies: A population-based matched case-control study. J Perinat Med 2012; 40(4): 379-82.
[http://dx.doi.org/10.1515/jpm-2011-0252] [PMID: 22752768]
[60]
Mostello D, Catlin TK, Roman L, Holcomb WL Jr, Leet T. Preeclampsia in the parous woman: Who is at risk? Am J Obstet Gynecol 2002; 187(2): 425-9.
[http://dx.doi.org/10.1067/mob.2002.123608] [PMID: 12193937]
[61]
Dalmáz CA, dos Santos KG, Botton MR, Roisenberg I. Fatores de risco para distúrbios hipertensivos durante a gravidez no Sul do Brasil. Rev Assoc Med Bras 2011; 57(6): 692-6.
[PMID: 22249551]
[62]
Melamed N, Hadar E, Peled Y, Hod M, Wiznitzer A, Yogev Y. Risk for recurrence of preeclampsia and outcome of subsequent pregnancy in women with preeclampsia in their first pregnancy. J Matern Fetal Neonatal Med 2012; 25(11): 2248-51.
[http://dx.doi.org/10.3109/14767058.2012.684174] [PMID: 22524456]
[63]
Danza A, Ruiz-Irastorza G, Khamashta M. Antiphospohlipid syndrome in obstetrics. Best Pract Res Clin Obstet Gynaecol 2012; 26(1): 65-76.
[http://dx.doi.org/10.1016/j.bpobgyn.2011.10.006] [PMID: 22079775]
[64]
Clark EAS, Silver RM, Ware Branch D. Do antiphospholipid antibodies cause preeclampsia and HELLP syndrome? Curr Rheumatol Rep 2007; 9(3): 219-25.
[http://dx.doi.org/10.1007/s11926-007-0035-9] [PMID: 17531175]
[65]
Wei SQ, Qi HP, Luo ZC, Fraser WD. Maternal vitamin D status and adverse pregnancy outcomes: A systematic review and meta-analysis. J Matern Fetal Neonatal Med 2013; 26(9): 889-99.
[http://dx.doi.org/10.3109/14767058.2013.765849] [PMID: 23311886]
[66]
Tabesh M, Salehi-Abargouei A, Tabesh M, Esmaillzadeh A. Maternal vitamin D status and risk of pre-eclampsia: A systematic review and meta-analysis. J Clin Endocrinol Metab 2013; 98(8): 3165-73.
[http://dx.doi.org/10.1210/jc.2013-1257] [PMID: 23783101]
[67]
Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A, Roberts LR. A global view of hepatocellular carcinoma: Trends, risk, prevention and management. Nat Rev Gastroenterol Hepatol 2019; 16(10): 589-604.
[http://dx.doi.org/10.1038/s41575-019-0186-y] [PMID: 31439937]
[68]
Irani M, Aradmehr M, Ghorbani M, Baghani R. Electromagnetic field exposure and abortion in pregnant women: A systematic review and meta-analysis. Malays J Med Sci 2023; 30(5): 70-80.
[http://dx.doi.org/10.21315/mjms2023.30.5.6] [PMID: 37928787]
[69]
Polak G, Bednarek W, Wertel I, et al. Endometriosis in adolescents. Springer 2013.
[70]
Agbayani Cruz CTA, Bucu MEM. Clinical profile and symptoms of young women aged 10–24 years diagnosed with pelvic endometriosis: A 5-year experience of a tertiary hospital in the Philippines. Journal of Endometriosis and Uterine Disorders 2024; 8: 100085.
[http://dx.doi.org/10.1016/j.jeud.2024.100085]
[71]
Singh S, Soliman AM, Rahal Y, et al. Prevalence, symptomatic burden, and diagnosis of Endometriosis in Canada: Cross-sectional survey of 30 000 women. J Obstet Gynaecol Can 2020; 42(7): 829-38.
[http://dx.doi.org/10.1016/j.jogc.2019.10.038] [PMID: 32001176]
[72]
Missmer SA, Tu F, Soliman AM, et al. Impact of endometriosis on women’s life decisions and goal attainment: A cross-sectional survey of members of an online patient community. BMJ Open 2022; 12(4): e052765.
[http://dx.doi.org/10.1136/bmjopen-2021-052765] [PMID: 35477879]
[73]
Matthys LA, Coppage KH, Lambers DS, Barton JR, Sibai BM. Delayed postpartum preeclampsia: An experience of 151 cases. Am J Obstet Gynecol 2004; 190(5): 1464-6.
[http://dx.doi.org/10.1016/j.ajog.2004.02.037] [PMID: 15167870]
[74]
Yancey LM, Withers E, Bakes K, Abbott J. Postpartum preeclampsia: Emergency department presentation and management. J Emerg Med 2011; 40(4): 380-4.
[http://dx.doi.org/10.1016/j.jemermed.2008.02.056] [PMID: 18814997]
[75]
Ghuman N, Rheiner J, Tendler BE, White WB. Hypertension in the postpartum woman: Clinical update for the hypertension specialist. J Clin Hypertens (Greenwich) 2009; 11(12): 726-33.
[http://dx.doi.org/10.1111/j.1751-7176.2009.00186.x]
[76]
Makris A, Thornton C, Hennessy A. Postpartum hypertension and nonsteroidal analgesia. Am J Obstet Gynecol 2004; 190(2): 577-8.
[http://dx.doi.org/10.1016/j.ajog.2003.08.030] [PMID: 14981414]
[77]
Wasden SW, Ragsdale ES, Chasen ST, Skupski DW. Impact of non-steroidal anti-inflammatory drugs on hypertensive disorders of pregnancy. Pregnancy Hypertens 2014; 4(4): 259-63.
[http://dx.doi.org/10.1016/j.preghy.2014.06.001] [PMID: 26104814]
[78]
Vigil-De Gracia P, Solis V, Ortega N. Ibuprofen versus acetaminophen as a post-partum analgesic for women with severe pre-eclampsia: Randomized clinical study. J Matern Fetal Neonatal Med 2017; 30(11): 1279-82.
[http://dx.doi.org/10.1080/14767058.2016.1210599] [PMID: 27384376]
[79]
Blue NR, Murray-Krezan C, Drake-Lavelle S, et al. Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: A double-masked, randomized controlled trial. Am J Obstet Gynecol 2018; 218(6): 616.e1-8.
[http://dx.doi.org/10.1016/j.ajog.2018.02.016] [PMID: 29505772]
[80]
Dartey AF, Dzansi G, Lotse CW, Obuobisa R, Afua Bosu CE, Afaya A. Midwives experiences of managing clients with eclampsia in a low resource setting: A qualitative descriptive study. SAGE Open Nurs 2022; 8: 23779608221094542.
[http://dx.doi.org/10.1177/23779608221094542] [PMID: 35600007]
[81]
Tita AT, Szychowski JM, Boggess K, et al. Treatment for mild chronic hypertension during pregnancy. N Engl J Med 2022; 386(19): 1781-92.
[http://dx.doi.org/10.1056/NEJMoa2201295] [PMID: 35363951]
[82]
Ceres R, Modroño A, Ruíz S, Lindheimer MD, Sibai B. Doppler velocimetry: Is it useful in preeclampsia? AJOG 2001; 185: 522-3.
[83]
Contraception E. Practice bulletin clinical management guidelines for obstetrician–gynecologISTS. Obstet Gynecol 2018; 4(1)
[84]
ACOG Practice Bulletin. Clinical management guidelines for Obstetrician-Gynecologists use of psychiatric medications during pregnancy and Lactation. Focus 2009; 7(3): 385-400.
[http://dx.doi.org/10.1176/foc.7.3.foc385]
[85]
Gasnier R, Valério EG, Lopes Ramos JG. Antihypertensive drugs in pregnancy. Fam Med Community Health 2013; 1(1): 37-50.
[http://dx.doi.org/10.15212/FMCH.2013.0106]
[86]
Kumari A, Rohatgi R, Singh A, Kumar R. Comparative study of intravenous hydralazine and labetalol in severe hypertensive disorders of pregnancy. Int J Reprod Contracept Obstet Gynecol 2020; 9(2): 675.
[http://dx.doi.org/10.18203/2320-1770.ijrcog20200357]
[87]
Booth JN, Anstey DE, Bello NA, et al. Race and sex differences in asleep blood pressure: The coronary artery risk development in young adults (CARDIA) study. J Clin Hypertens (Greenwich) 2019; 21(2): 184-92.
[http://dx.doi.org/10.1111/jch.13474] [PMID: 30719843]
[88]
Guclu S, Gol M, Saygili U, Demir N, Sezer O, Baschat AA. Nifedipine therapy for preterm labor: Effects on placental, fetal cerebral and atrioventricular Doppler parameters in the first 48 hours. Ultrasound Obstet Gynecol 2006; 27(4): 403-8.
[http://dx.doi.org/10.1002/uog.2728] [PMID: 16565996]
[89]
Brown MA, Magee LA, Kenny LC, Karumanchi SA, McCarthy FP, Saito S, et al. Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice Hypertension 2018; 72(1): 24-43.
[90]
Magee LA, Pels A, Helewa M, Rey E, Von Dadelszen P. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy. Pregnancy Hypertension. Elsevier B.V. 2014; Vol. 4: pp. 105-45.
[91]
Kattah AG, Garovic VD. The management of hypertension in pregnancy. Adv Chronic Kidney Dis 2013; 20(3): 229-39.
[http://dx.doi.org/10.1053/j.ackd.2013.01.014] [PMID: 23928387]
[92]
Poniedziałek-Czajkowska E, Mierzyński R, Dłuski D, Leszczyńska-Gorzelak B. Prevention of hypertensive disorders of pregnancy—Is there a place for Metformin? J Clin Med 2021; 10(13): 2805.
[http://dx.doi.org/10.3390/jcm10132805] [PMID: 34202343]
[93]
Garovic VD, Dechend R, Easterling T, Karumanchi SA, Baird SMM, Magee LA, et al. Hypertension in pregnancy: Diagnosis, blood pressure goals, and Pharmacotherapy: A scientific statement from the american heart association Hypertension 2022; 79(2): e21-41.
[94]
Beech A, Mangos G. Management of hypertension in pregnancy. Aust Prescr 2021; 44(5): 148-52.
[http://dx.doi.org/10.18773/austprescr.2021.039] [PMID: 34728879]
[95]
Poon LC, Magee LA, Verlohren S, et al. A literature review and best practice advice for second and third trimester risk stratification, monitoring, and management of pre-eclampsia. Int J Gynaecol Obstet 2021; 154(S1) (Suppl. 1): 3-31.
[http://dx.doi.org/10.1002/ijgo.13763] [PMID: 34327714]
[96]
Rana S, Lemoine E, Granger JP, Karumanchi SA. Preeclampsia. Circ Res 2019; 124(7): 1094-112.
[http://dx.doi.org/10.1161/CIRCRESAHA.118.313276] [PMID: 30920918]
[97]
Hauth JC, Ewell MG, Levine RJ, et al. Pregnancy outcomes in healthy nulliparas who developed hypertension. Obstet Gynecol 2000; 95(1): 24-8.
[PMID: 10636496]
[98]
Knuist M, Bonsel GJ, Zondervan HA, Treffers PE. Intensification of fetal and maternal surveillance in pregnant women with hypertensive disorders. Int J Gynaecol Obstet 1998; 61(2): 127-33.
[http://dx.doi.org/10.1016/S0020-7292(98)00024-1] [PMID: 9639216]
[99]
Chen MH. A systematic review of the blood pressure lowering efficacy of diuretics as second-line therapy for primary hypertension.
[100]
Sibai BM, Hauth J, Caritis S, et al. Hypertensive disorders in twin versus singleton gestations. Am J Obstet Gynecol 2000; 182(4): 938-42.
[http://dx.doi.org/10.1016/S0002-9378(00)70350-4] [PMID: 10764477]
[101]
Buchbinder A, Sibai BM, Caritis S, et al. Adverse perinatal outcomes are significantly higher in severe gestational hypertension than in mild preeclampsia. Am J Obstet Gynecol 2002; 186(1): 66-71.
[http://dx.doi.org/10.1067/mob.2002.120080] [PMID: 11810087]

Rights & Permissions Print Cite
© 2025 Bentham Science Publishers | Privacy Policy