Abstract
L-Arginine is one of the most commonly used and most generally applicable suppressors of protein aggregation. Its effect as enhancer of in vitro protein refolding was serendipitously discovered two decades ago. This article aims at giving a brief overview about the discovery of the arginine effect, the range of its applications that have been explored over the past two decades, and of the current state of the discussion regarding the mechanisms responsible for the action of L-arginine as suppressor of aggregation.
Keywords: Arginine, in vitro-refolding, protein aggregation, aggregation suppressor
Current Pharmaceutical Biotechnology
Title: Suppression of Protein Aggregation by L-Arginine
Volume: 10 Issue: 4
Author(s): Christian Lange and Rainer Rudolph
Affiliation:
Keywords: Arginine, in vitro-refolding, protein aggregation, aggregation suppressor
Abstract: L-Arginine is one of the most commonly used and most generally applicable suppressors of protein aggregation. Its effect as enhancer of in vitro protein refolding was serendipitously discovered two decades ago. This article aims at giving a brief overview about the discovery of the arginine effect, the range of its applications that have been explored over the past two decades, and of the current state of the discussion regarding the mechanisms responsible for the action of L-arginine as suppressor of aggregation.
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Cite this article as:
Lange Christian and Rudolph Rainer, Suppression of Protein Aggregation by L-Arginine, Current Pharmaceutical Biotechnology 2009; 10 (4) . https://dx.doi.org/10.2174/138920109788488851
DOI https://dx.doi.org/10.2174/138920109788488851 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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