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Current Gene Therapy

Editor-in-Chief

ISSN (Print): 1566-5232
ISSN (Online): 1875-5631

Review Article

Immune Modulation Strategies in Gene Therapy: Overcoming Immune Barriers and Enhancing Efficacy

In Press, (this is not the final "Version of Record"). Available online 02 October, 2024
Author(s): Sivaprakasam S. Amsaveni, Radha Mahendran, Vidhya C. S., Dilip Kumar Chanchal*, Sojomon Mathew, Mukesh Chandra Sharma, Jailani S. and Syed Salman Ali
Published on: 02 October, 2024

DOI: 10.2174/0115665232305409240918040639

Price: $95

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Abstract

The immune system presents significant obstacles to gene therapy, which has limited its use in treating many illnesses. New approaches are needed to overcome these problems and improve the effectiveness of gene therapy. This study explores several techniques to immune regulation within gene therapy, a cutting-edge discipline that aims to optimise results by fine-tuning the immune response. We cover new ways to control the immune system and deliver therapeutic genes just where they are needed, including influencing immunological checkpoints, causing immunotolerance, and making smart use of immunomodulatory drugs. In addition, the study provides insight into new developments in the design of less immunogenic gene delivery vectors, which allow for the extension of transgene expression with minimal adverse immune reactions. In order to maximise the efficacy of gene-based therapies, this review analyses these novel approaches and gives a thorough overview of the present state of the art by addressing obstacles and pointing the way toward future developments in immune regulation. Not only does their integration provide new opportunities for the creation of safer and more effective gene treatments, but it also contains the key to overcome current obstacles.

Keywords: Gene therapy, immune modulation, immunotolerance, immune checkpoints, immunomodulatory agents, gene delivery vectors.


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