Abstract
The INhibitor of Growth (ING) genes were discovered during the past decade and identified as type II tumor suppressor genes. Previous studies demonstrated that ING family members participate in various cellular stress responses and thus play important roles in the pathogenesis of various types of cancers, including melanoma. Epidemiological studies showed that UV radiation is the primary etiological factor in melanoma development. Here we review the studies on the role of ING proteins in cellular responses to UV irradiation, melanoma cell motility, and melanoma progression.
Keywords: ING, tumor suppressor, melanoma, UV irradiation, stress response
Current Drug Targets
Title: The Role of ING Tumor Suppressors in UV Stress Response and Melanoma Progression
Volume: 10 Issue: 5
Author(s): Jun Li, Yemin Wang, Ronald P.C. Wong and Gang Li
Affiliation:
Keywords: ING, tumor suppressor, melanoma, UV irradiation, stress response
Abstract: The INhibitor of Growth (ING) genes were discovered during the past decade and identified as type II tumor suppressor genes. Previous studies demonstrated that ING family members participate in various cellular stress responses and thus play important roles in the pathogenesis of various types of cancers, including melanoma. Epidemiological studies showed that UV radiation is the primary etiological factor in melanoma development. Here we review the studies on the role of ING proteins in cellular responses to UV irradiation, melanoma cell motility, and melanoma progression.
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Cite this article as:
Li Jun, Wang Yemin, Wong P.C. Ronald and Li Gang, The Role of ING Tumor Suppressors in UV Stress Response and Melanoma Progression, Current Drug Targets 2009; 10 (5) . https://dx.doi.org/10.2174/138945009788185031
DOI https://dx.doi.org/10.2174/138945009788185031 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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