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Review Article

Quercetin in Oncology: A Phytochemical with Immense Therapeutic Potential

Author(s): Raj Kamal, Priyanka Paul, Shubham Thakur, Sachin Kumar Singh and Ankit Awasthi*

Volume 25, Issue 11, 2024

Published on: 10 July, 2024

Page: [740 - 751] Pages: 12

DOI: 10.2174/0113894501292466240627050638

Price: $65

Abstract

Quercetin is a natural flavonoid with various pharmacological actions such as anti-inflammatory, antioxidant, antimicrobial, anticancer, antiviral, antidiabetic, cardioprotective, neuroprotective, and antiviral activities. Looking at these enormous potentials, researchers have explored how they can be used to manage numerous cancers. It's been studied for cancer management due to its anti-angiogenesis, anti-metastatic, and antiproliferative mechanisms. Despite having these proven pharmacological activities, the clinical use of quercetin is limited due to its first-- pass metabolism, poor solubility, and bioavailability. To address these shortcomings, researchers have fabricated various nanocarriers-based formulations to fight cancer. The present review overshadows the pharmacological potential, mechanisms, and application of nanoformulations against different cancers.

Teaser: Explore the potential of Quercetin, a natural flavonoid with diverse pharmacological activities, and its nanoformulations in managing various cancers.

Keywords: Quercetin, pharmacotherapeutic activities, anticancer activities, nanoformulations, clinical trials, medicinal plants.

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Graphical Abstract

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