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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Biosensors for Detection of Hepatitis B Virus: Review

In Press, (this is not the final "Version of Record"). Available online 11 June, 2024
Author(s): Amir Hossein Esfandiari, Hadis Hajipir Farkhani, Zahra Hashemi Javan, Arastoo Vojdani, Mahla Velayati, Hanie Mahaki, Zahra Meshkat, Hamed Manoochehri, Amir Avan and Hamid Tanzadehpanah*
Published on: 11 June, 2024

DOI: 10.2174/0109298673295474240531100312

Price: $95


Hepatitis B is still one of the most important infectious diseases among humans, which is considered a serious threat to their lives. Early diagnosis of this disease can be an effective measure in stopping the chain of transmission and treatment of the disease. In this review study, an attempt has been made to explain the use of biosensors as a fast, high-efficiency, and low-cost method in diagnosis. The biosensors prepared for hepatitis detection included DNA-based, aptamers-based, protein-based, enzyme-based, antibody-based, and polymers-based biosensors, each of which had different advantages. The results of this review showed that almost all introduced biosensors had an acceptable performance. However, we suggest that aptamers are desirable for biosensing applications because they can change their structure to properly bind to their target, are cost-effective to prepare, and are highly sensitive.

Keywords: Hepatitis B, liver Infection, DNA-based biosensors, aptamers-based biosensors, antibody-based biosensors, diagnosis.

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