Abstract
Background: Assessing the efficacy of remdesivir for COVID-19 infection holds historical significance. Understanding its effectiveness from previous pandemic instances can enable us to gain insights into its efficacy, informing our strategies for responding to future outbreaks or variants.
Objective: Gaining an insight into the historical efficacy of remdesivir can offer valuable data for evaluating the advancement of COVID-19 treatments and the development of medical expertise in handling the disease.
Method: The historical data regarding the effectiveness of remdesivir can enrich the pool of knowledge and evidence accessible for public health planning and decision-making. Understanding whether remdesivir was efficacious in previous instances may aid in comprehending its real-world impact on patient outcomes at those times. Such insights are crucial for evaluating treatment efficacy and refining strategies based on past experiences.
Results: In the late treatment of severe COVID-19 cases, which are particularly challenging, remdesivir has demonstrated a 6% improvement.
Conclusion: The 6% enhanced effect of remdesivir is not substantial, considering that it is an unweighted average of works with varying degrees of importance and reliability. Additionally, there are instances where conflicts of interest may have impacted the results. It is also possible that the observed improvement could be attributed to better patient care in certain environments.
Keywords: Remdesivir, COVID-19, ARDS, severe ARDS, ICU care, virology.
[http://dx.doi.org/10.1038/s41422-020-0282-0] [PMID: 32020029]
[http://dx.doi.org/10.1016/j.antiviral.2020.104786] [PMID: 32251767]
[http://dx.doi.org/10.1016/S0140-6736(20)31324-6] [PMID: 32511943]
[http://dx.doi.org/10.1126/scitranslmed.aal3653] [PMID: 28659436]
[http://dx.doi.org/10.1074/jbc.RA120.013679] [PMID: 32284326]
[http://dx.doi.org/10.1021/acscentsci.0c00489] [PMID: 32483554]
[http://dx.doi.org/10.1038/d41573-020-00016-0] [PMID: 32127666]
[http://dx.doi.org/10.1038/s41467-020-20542-0] [PMID: 33436624]
[http://dx.doi.org/10.1016/j.arcmed.2020.05.001] [PMID: 32439198]
[http://dx.doi.org/10.1111/fcp.12643] [PMID: 33369768]
[http://dx.doi.org/10.1016/j.ijantimicag.2022.106542] [PMID: 35093538]
[http://dx.doi.org/10.1073/pnas.1922083117] [PMID: 32054787]
[http://dx.doi.org/10.1038/s41586-020-2324-7] [PMID: 32396922]
[http://dx.doi.org/10.1038/s41586-020-2423-5] [PMID: 32516797]
[http://dx.doi.org/10.1016/S0140-6736(20)31022-9] [PMID: 32423584]
[http://dx.doi.org/10.1177/0885066621994476] [PMID: 33685275]
[http://dx.doi.org/10.1056/NEJMoa2007764] [PMID: 32445440]
[http://dx.doi.org/10.1001/jama.2020.16349] [PMID: 32821939]
[http://dx.doi.org/10.1101/2020.06.22.20136531]
[http://dx.doi.org/10.1101/2020.11.19.20234153]
[http://dx.doi.org/10.1056/NEJMoa2015301] [PMID: 32459919]
[http://dx.doi.org/10.1007/s15010-020-01557-7] [PMID: 33389708]
[PMID: 33350698]
[http://dx.doi.org/10.1056/NEJMoa2007016] [PMID: 32275812]
[http://dx.doi.org/10.18483/ijSci.2417]
[http://dx.doi.org/10.1016/j.ijid.2020.06.093] [PMID: 32619764]
[http://dx.doi.org/10.1177/0018578721999804] [PMID: 37711410]
[http://dx.doi.org/10.1016/S0140-6736(19)32527-9] [PMID: 31785827]
[http://dx.doi.org/10.1002/cpt.2145] [PMID: 33340409]
[http://dx.doi.org/10.3389/fphar.2022.833679] [PMID: 35370750]
[http://dx.doi.org/10.1016/bs.podrm.2022.11.003] [PMID: 37061276]
[http://dx.doi.org/10.3390/ph14070655] [PMID: 34358081]
[http://dx.doi.org/10.1021/acs.joc.3c00754] [PMID: 37276453]
[http://dx.doi.org/10.1016/j.coviro.2021.04.014] [PMID: 34052732]
[http://dx.doi.org/10.1016/j.jbc.2022.102169] [PMID: 35732208]
[http://dx.doi.org/10.1016/j.nanoen.2023.108362]
[http://dx.doi.org/10.1016/j.compositesb.2021.109609]
[http://dx.doi.org/10.1002/poc.4156]