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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry


ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

Review Article

Decades Long Involvement of THP-1 Cells as a Model for Macrophage Research: A Comprehensive Review

Author(s): Prakhar Sharma, Kaliyamurthi Venkatachalam and Ambika Binesh*

Volume 23, Issue 2, 2024

Published on: 26 April, 2024

Page: [85 - 104] Pages: 20

DOI: 10.2174/0118715230294413240415054610

Price: $65


Over the years, researchers have endeavored to identify dependable and reproducible in vitro models for examining macrophage behavior under controlled conditions. The THP-1 cell line has become a significant and widely employed tool in macrophage research within these models. Originating from the peripheral blood of individuals with acute monocytic leukemia, this human monocytic cell line can undergo transformation into macrophage-like cells, closely mirroring primary human macrophages when exposed to stimulants. Macrophages play a vital role in the innate immune system, actively regulating inflammation, responding to infections, and maintaining tissue homeostasis. A comprehensive understanding of macrophage biology and function is crucial for gaining insights into immunological responses, tissue healing, and the pathogenesis of diseases such as viral infections, autoimmune disorders, and neoplastic conditions. This review aims to thoroughly evaluate and emphasize the extensive history of THP-1 cells as a model for macrophage research. Additionally, it will delve into the significance of THP-1 cells in advancing our comprehension of macrophage biology and their invaluable contributions to diverse scientific domains.

Keywords: THP-1, in vitro models, macrophage research, peripheral blood, acute monocytic leukemia, homeostasis.

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