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Current Organocatalysis

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Review Article

Solvent-Free Synthesis of Bioactive Heterocycles

Author(s): Sangeeta Bajpai*, Monika Kamboj*, Surabhi Singh, Monika Yadav and Bimal Krishna Banik

Volume 11, Issue 4, 2024

Published on: 09 April, 2024

Page: [301 - 309] Pages: 9

DOI: 10.2174/0122133372300414240403035407

Price: $65

Abstract

The main emphasis of green chemistry is to reduce environmental pollution. Its main goal is to adopt a cost-effective and harmless strategy for human health and the environment. The green synthetic routes have succeeded in adopting solvent-free conditions as an effective tool for sustainability. Heterocycles are organic compounds that are widely distributed by nature. Many of them possess medicinal and pharmacological properties, as this heterocyclic moiety is found in many drugs. The solvent-free strategies for the Synthesis of bioactive heterocycles are, nowadays, regarded as an important objective. Solvent-free reactions are eco-friendly, cost-effective, and an environmentally benign route in organic transformation methods because of their efficiency, reduced reaction time, and high yields, thereby saving energy. This mini-review focuses on the environmentally benign solvent-free Synthesis of heterocycles and their potential pharmacological applications.

Keywords: Solvent-free synthesis, Bioactive Heterocycles, HClO4-SiO2 catalyst, Ultrasound, Pharmacological applications, dihydropyrimidines.

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