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Current Drug Research Reviews

Editor-in-Chief

ISSN (Print): 2589-9775
ISSN (Online): 2589-9783

Meta-Analysis

The Relationship between Statin Intake and Risk of Pancreatic Cancer: A Systematic Review and Meta-Analysis

In Press, (this is not the final "Version of Record"). Available online 20 March, 2024
Author(s): Hesamaldin Bagheri, Omid-Ali Adeli*, Saeid Heidari-Soureshjani, Zahra Azadegan-Dehkordi and Catherine MT Sherwin
Published on: 20 March, 2024

DOI: 10.2174/0125899775281869240311043637

Price: $95

Abstract

Background: Pancreatic neoplasm is one of the types of cancer with a high incidence and case-fatality rate.

Objectives: This study was designed to investigate the relationship between statin intake and the risk of pancreatic cancer with a systematic review and meta-analysis approach.

Methods: This study was a systematic review and meta-analysis of studies published before 2023 in Cochrane Library, Web of Science (WOS), PubMed, Google Scholar, ScienceDirect, Scopus, and Embase databases. The statistical analyses were conducted using Stata software, version 15. The significance level for this study was set at 0.05.

Results: This meta-analysis included 32 studies and a total of 5,849,814 participants. The risk ratio (RR) of pancreatic cancer in comparison to the non-statin receiving group in statin users in total was equal to 0.75 (95% CI: 0.66-0.86, p-value <0.001), in the cohort studies was obtained to be 0.70 (0.53-0.93), in the randomized clinical trials (RCTs) had a ratio of 0.99 (0.53-1.86), while studies conducted in American countries had a ratio of 0.69 (0.51-0.93), studies in Asian countries had a ratio of 0.73 (0.56-0.97), and studies in European countries had a ratio of 0.88 (0.76-1.02). Furthermore, the study did not detect any signs of publication bias.

Conclusion: The study findings suggest a potential connection between using statins and a lower risk of pancreatic cancer. However, it is important to note that controlled clinical trials did not find a statistically significant association between taking statins and the development of pancreatic cancer. Therefore, it is advisable to exercise caution when interpreting the results of this study.

Keywords: Statin, pancreatic cancer, pancreas neoplasm, mortality, meta-analysis, systematic review.


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