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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Regulation of Matrix Synthesis, Remodeling and Accumulation in Glomerulosclerosis

Author(s): Ambra Pozzi, Paul A. Voziyan, Billy G. Hudson and Roy Zent

Volume 15, Issue 12, 2009

Page: [1318 - 1333] Pages: 16

DOI: 10.2174/138161209787846748

Price: $65


After injury the body normally undergoes a repair process, however when this event becomes deregulated the pathological condition of fibrosis occurs. There are many similarities with respect to the fundamental mechanisms that regulate sclerosis in different organ systems. In this review we utilize the pathological entity of glomerulosclerosis in the kidney to highlight some of the general paradigms whereby extracellular matrix (ECM) is deposited in greater quantities than it is degraded. Our review discusses how genetic and structural abnormalities of specific ECM components can result in fibrosis. In addition, we outline how some key growth factors, integrins and oxidative stress play a role in the development of glomerulosclerosis.

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