Abstract
The determination of post-translational modifications is one of the main challenges in proteomics research. Mass spectrometry is a powerful tool for the structural characterization of proteins and different mass spectrometric techniques for the analysis of post-translational modifications of individual proteins or protein populations have been developed. This review describes the most recent advances in mass spectrometry-based approaches for the detection and determination of post-translational modifications, with an emphasis on glycosylation and phosphorylation.
Keywords: Mass spectrometry, Proteomics, Glycomics, Glycosylation, Phosphorylation, Glycoproteomics, Structural analysis
Current Analytical Chemistry
Title: Analysis of Glycosylation and Other Post-Translational Modifications by Mass Spectrometry
Volume: 5 Issue: 2
Author(s): Willy Morelle
Affiliation:
Keywords: Mass spectrometry, Proteomics, Glycomics, Glycosylation, Phosphorylation, Glycoproteomics, Structural analysis
Abstract: The determination of post-translational modifications is one of the main challenges in proteomics research. Mass spectrometry is a powerful tool for the structural characterization of proteins and different mass spectrometric techniques for the analysis of post-translational modifications of individual proteins or protein populations have been developed. This review describes the most recent advances in mass spectrometry-based approaches for the detection and determination of post-translational modifications, with an emphasis on glycosylation and phosphorylation.
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Cite this article as:
Morelle Willy, Analysis of Glycosylation and Other Post-Translational Modifications by Mass Spectrometry, Current Analytical Chemistry 2009; 5 (2) . https://dx.doi.org/10.2174/157341109787846153
DOI https://dx.doi.org/10.2174/157341109787846153 |
Print ISSN 1573-4110 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6727 |
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