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Current Analytical Chemistry


ISSN (Print): 1573-4110
ISSN (Online): 1875-6727

Analysis of Glycosylation and Other Post-Translational Modifications by Mass Spectrometry

Author(s): Willy Morelle

Volume 5, Issue 2, 2009

Page: [144 - 165] Pages: 22

DOI: 10.2174/157341109787846153

Price: $65


The determination of post-translational modifications is one of the main challenges in proteomics research. Mass spectrometry is a powerful tool for the structural characterization of proteins and different mass spectrometric techniques for the analysis of post-translational modifications of individual proteins or protein populations have been developed. This review describes the most recent advances in mass spectrometry-based approaches for the detection and determination of post-translational modifications, with an emphasis on glycosylation and phosphorylation.

Keywords: Mass spectrometry, Proteomics, Glycomics, Glycosylation, Phosphorylation, Glycoproteomics, Structural analysis

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