Modulation of Angiotensin-II and Angiotensin 1-7 Levels Influences Cardiac Function in Myocardial Ischemia-reperfusion Injury

Title:Modulation of Angiotensin-II and Angiotensin 1-7 Levels Influences Cardiac Function in Myocardial Ischemia-reperfusion Injury

Volume: 17 Issue: 1

Author(s): Prabhat Kumar Upadhyay, Navneet Thakur, Vishal Kumar Vishwakarma*, Hridaya Shankar Chaurasiya and Tarique Mahmood Ansari

Affiliation:

• Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India

Keywords: Heart, renin-angiotensin system, myocardial ischemia-reperfusion injury, ACE-2 activator, ACE inhibitor, angiotensin-II antagonist.

Abstract: The angiotensin-converting enzyme-2 (ACE-2) alters the pathophysiology of various fatal cardiovascular diseases, including ischemic heart disease, whereas angiotensin 1-7 (Ang 1–7) exerts a wide range of actions. The effects of ischemia-reperfusion (IR) injury include damage to myocardial tissue that initiates protease action, causing cardiac cell death. Angiotensin- II (Ang-II) contributes through the renin-angiotensin system (RAS) to the IR injury, whereas Ang 1–7 paradoxically exerts a protective effect through the same. Thus, the myocardial ischemic reperfusion injury (MIRI) may be altered by the RAS of the heart. This review paper focuses on ACE-2, angiotensin-converting enzyme (ACE), and Ang 1–7 regulation in the RAS of the heart in the pathophysiology of MIRI. The treatment in such conditions using ACE-2 activator, ACE inhibitor, and Ang-II antagonists may promote vascular functions as well as cardio- protection.

Cite this article as:

Upadhyay Kumar Prabhat, Thakur Navneet, Vishwakarma Kumar Vishal*, Chaurasiya Shankar Hridaya and Ansari Mahmood Tarique, Modulation of Angiotensin-II and Angiotensin 1-7 Levels Influences Cardiac Function in Myocardial Ischemia-reperfusion Injury, Current Drug Research Reviews 2025; 17 (1) . https://dx.doi.org/10.2174/0125899775280160240122065607