Advancements in the Research of GEF-H1: Biological Functions and Tumor Associations

Title:Advancements in the Research of GEF-H1: Biological Functions and Tumor Associations

Volume: 17

Author(s): Liqi Li, Yunyun Li*Xiaoshu Zhou*

Affiliation:

• Department of Neurology, The 942 Hospital of PLA, Yinchuan, Ningxia Hui Autonomous Region, 750001, China

• College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China

Keywords: GEF-H1, Rho GTPase, Guanine nucleotide exchange factor, ARHGEF2, Cancer, RhoA.

Abstract: Guanine nucleotide exchange factor H1 (GEF-H1) is a unique protein modulated by the GDP/GTP exchange. As a regulator of the Rho-GTPase family, GEF-H1 can be activated through a microtubule-depended mechanism and phosphorylation regulation, enabling it to perform various pivotal biological functions across multiple cellular activities. These include the regulation of Rho-GTPase, cytoskeleton formation, cellular barrier, cell cycle, mitosis, cell differentiation, and vesicle trafficking. Recent studies have revealed its crucial effect on the tumor microenvironment (TME) components, promoting tumor initiation and progress. Consequently, an in-depth exploration of GEF-H1’s biological roles and association with tumors holds promise for its potential as a valuable molecular target in tumor treatment.

Cite this article as:

Li Liqi, Li Yunyun*, Zhou Xiaoshu*, Advancements in the Research of GEF-H1: Biological Functions and Tumor Associations, Current Molecular Pharmacology 2024; 17 : e18761429274883 . https://dx.doi.org/10.2174/0118761429274883231129103220