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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Systematic Review Article

Genetic and Epigenetic Determinants of COVID-19 Susceptibility: A Systematic Review

In Press, (this is not the final "Version of Record"). Available online 19 January, 2024
Author(s): Amin Gasmi, Laura Kassym, Alain Menzel, Wajiha Anzar, Maryam Dadar, Yuliya Semenova, Mehreen Arshad, Tetyana Bihunyak, Nagwa Abdel Meguid, Massimiliano Peana, Zhanagul Bekbergenova and Geir Bjørklund*
Published on: 19 January, 2024

DOI: 10.2174/0109298673267890231221100659

Price: $95


Background: The molecular mechanisms regulating coronavirus pathogenesis are complex, including virus-host interactions associated with replication and innate immune control. However, some genetic and epigenetic conditions associated with comorbidities increase the risk of hospitalization and can prove fatal in infected patients. This systematic review will provide insight into host genetic and epigenetic factors that interfere with COVID-19 expression in light of available evidence.

Methods: This study conducted a systematic review to examine the genetic and epigenetic susceptibility to COVID-19 using a comprehensive approach. Through systematic searches and applying relevant keywords across prominent online databases, including Scopus, PubMed, Web of Science, and Science Direct, we compiled all pertinent papers and reports published in English between December 2019 and June 2023.

Results: The findings reveal that the host's HLA genotype plays a substantial role in determining how viral protein antigens are showcased and the subsequent immune system reaction to these antigens. Within females, genes responsible for immune system regulation are found on the X chromosome, resulting in reduced viral load and inflammation levels when contrasted with males. Possessing blood group A may contribute to an increased susceptibility to contracting COVID-19 as well as a heightened risk of mortality associated with the disease. The capacity of SARS-CoV-2 involves inhibiting the antiviral interferon (IFN) reactions, resulting in uncontrolled viral multiplication.

Conclusion: There is a notable absence of research into the gender-related predisposition to infection, necessitating a thorough examination. According to the available literature, a significant portion of individuals affected by the ailment or displaying severe ramifications already had suppressed immune systems, categorizing them as a group with elevated risk.

Keywords: novel coronavirus, COVID-19, genetic, epigenetic, comorbidities, molecular mechanisms.

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