Abstract
Management of pain and anxiety for children requiring urgent care has progressed dramatically in the past decade. However, the administration of analgesia and sedation in children is inconsistent, with significant practice variation among practitioners, and especially amid younger children who receive less than optimal analgesia. Nasal administrations of drugs have several significant advantages over current practices. The nose has a very rich vascular supply, it facilitates direct absorption to the systemic blood supply and increases bioavailability of the drug, compared to oral administration. The current review summarizes available information on the use of intranasal drug delivery for children in acute illness. Midazolam (Versed), Fentanyl, Diamorphine and Ketamine are discussed, as well as pitfalls and caveats of intranasal drug use.
Keywords: bioavailability, nasal cavity, Drug delivery, controlled trails, Benzodiazepins, Intranasal fentanyl
Current Drug Therapy
Title: Intranasal Drug Delivery for Children with Acute Illness
Volume: 1 Issue: 1
Author(s): Ran D. Goldman
Affiliation:
Keywords: bioavailability, nasal cavity, Drug delivery, controlled trails, Benzodiazepins, Intranasal fentanyl
Abstract: Management of pain and anxiety for children requiring urgent care has progressed dramatically in the past decade. However, the administration of analgesia and sedation in children is inconsistent, with significant practice variation among practitioners, and especially amid younger children who receive less than optimal analgesia. Nasal administrations of drugs have several significant advantages over current practices. The nose has a very rich vascular supply, it facilitates direct absorption to the systemic blood supply and increases bioavailability of the drug, compared to oral administration. The current review summarizes available information on the use of intranasal drug delivery for children in acute illness. Midazolam (Versed), Fentanyl, Diamorphine and Ketamine are discussed, as well as pitfalls and caveats of intranasal drug use.
Export Options
About this article
Cite this article as:
Goldman D. Ran, Intranasal Drug Delivery for Children with Acute Illness, Current Drug Therapy 2006; 1 (1) . https://dx.doi.org/10.2174/157488506775268470
DOI https://dx.doi.org/10.2174/157488506775268470 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Dietary Additive Probiotics Modulation of the Intestinal Microbiota
Protein & Peptide Letters Gene Therapy by Liver Transplantation and Single Stranded Oligonucleotides (SSOs) in Familial Amyloidotic Polyneuropathy (FAP)
Current Pharmacogenomics Biomarkers and Osteosarcoma and IGF
Recent Patents on Biomarkers A Review on Post-traumatic Stress Disorder (PTSD): Symptoms, Therapies and Recent Case Studies
Current Molecular Pharmacology Epidemics of Obesity and Metabolic Disorders: Are Dietary Fats or Sugars Involved?
Current Nutrition & Food Science Vitamin D and Cardiovascular Disease: A Novel Agent for Reducing Cardiovascular Risk?
Current Vascular Pharmacology Psychosocial Risk Factors Related to Ischemic Heart Disease in Women
Current Pharmaceutical Design Multifunctional Proteins in Tumorigenesis: Aminoacyl-tRNA Synthetases and Translational Components
Current Proteomics Melatonin: Pharmacology, Functions and Therapeutic Benefits
Current Neuropharmacology Crosstalk Between The Immune Receptors and Gut Microbiota
Current Protein & Peptide Science Modifiable Midlife Risk Factors for Late-Life Cognitive Impairment and Dementia
Current Psychiatry Reviews Subject Index To Volume 3
Current Genomics Development and Clinical Application of Peptide-Based Radiopharmaceuticals
Current Pharmaceutical Design Atoh1: Landscape for Inner Ear Cell Regeneration
Current Gene Therapy Personalized Medicine Using Cutting Edge Technologies for Genetic Epilepsies
Current Neuropharmacology Immunomodulation in Inflammatory Neuropathies: Rationale and Safety
Current Drug Safety A Molecular Link Between Diabetes and Breast Cancer: Therapeutic Potential of Repurposing Incretin-based Therapies for Breast Cancer
Current Cancer Drug Targets Genitourinary Tract Tumors in Children: An Update
Current Pediatric Reviews Nenatal Drug Induced Nephrotoxicity : Old and Next Generation Biomarkers for Early Detection and Management of Neonatal Drug-Induced Nephrotoxicity, with Special Emphasis on uNGAL and on Metabolomics
Current Medicinal Chemistry Patent Selections:
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery