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Current Cancer Therapy Reviews

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ISSN (Print): 1573-3947
ISSN (Online): 1875-6301

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Perspective

Childhood Heart Tumors: Detection, Diagnosis, and Treatments

Author(s): Megala Jayaraman* and Diveyaa Sivakumar

Volume 20, Issue 6, 2024

Published on: 13 December, 2023

Page: [523 - 528] Pages: 6

DOI: 10.2174/0115733947272587231115074506

Abstract

Childhood cardiac tumors are rare but challenging conditions that can have a significant impact on a child’s health and even be fatal if not detected and diagnosed timely. While various types of tumors can occur in the heart, the most common among children are benign tumors, such as rhabdomyomas. Diagnosis of pediatric cardiac tumors is often challenging and requires a combination of clinical examination, imaging studies and biopsy. In some cases, the tumors may be asymptomatic and discovered incidentally, while in others, they can cause symptoms, such as shortness of breath, chest pain, arrhythmias and congestive heart failure. Treatment options for pediatric cardiac tumors vary depending on the type, size and location of the tumor and may include surgical resection, watchful waiting or a combination of both. The prognosis for children with cardiac tumors is generally good, with a high rate of complete cure in many cases. However, long-term follow-up and monitoring are important to detect and manage any potential complications or recurrence of the tumors.

Keywords: Fetal echocardiography, fibromas, hemangiomas, myxomas, rhabdomyomas, teratomas, purkinje cell tumor.

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Graphical Abstract

[1]
Yuan SM. Fetal cardiac tumors: Clinical features, management and prognosis. J Perinat Med 2018; 46(2): 115-21.
[http://dx.doi.org/10.1515/jpm-2016-0311] [PMID: 28343178]
[2]
Uzun O, Wilson DG, Vujanic GM, Parsons JM, De Giovanni JV. Cardiac tumours in children. Orphanet J Rare Dis 2007; 2(1): 11.
[http://dx.doi.org/10.1186/1750-1172-2-11] [PMID: 17331235]
[3]
Yinon Y, Chitayat D, Blaser S, et al. Fetal cardiac tumors: A single‐center experience of 40 cases. Prenat Diagn 2010; 30(10): 941-9.
[http://dx.doi.org/10.1002/pd.2590] [PMID: 20721876]
[4]
Wei J, Li P, Chiriboga L, et al. Tuberous sclerosis in a 19-week fetus: Immunohistochemical and molecular study of hamartin and tuberin. Pediatr Dev Pathol 2002; 5(5): 448-64.
[http://dx.doi.org/10.1007/s10024-001-0210-3] [PMID: 12202993]
[5]
Wacker-Gussmann A, Strasburger JF, Cuneo BF, Wiggins DL, Gotteiner NL, Wakai RT. Fetal arrhythmias associated with cardiac rhabdomyomas. Heart Rhythm 2014; 11(4): 677-83.
[http://dx.doi.org/10.1016/j.hrthm.2013.12.018] [PMID: 24333285]
[6]
Yin L, He D, Shen H, et al. Surgical treatment of cardiac tumors: A 5-year experience from a single cardiac center. J Thorac Dis 2016; 8(5): 911-9.
[http://dx.doi.org/10.21037/jtd.2016.03.87] [PMID: 27162666]
[7]
Qian T, Wu Z, Yang Y, et al. Surgery for primary cardiac tumors in children: Successful management of large fibromas. Front Cardiovasc Med 2022; 9: 808394.
[http://dx.doi.org/10.3389/fcvm.2022.808394] [PMID: 35321111]
[8]
Sanad M, Arafa S, Hegazy MA, Abdel Hamid WAA. Primary cardiac tumors: A spectrum of pathologies and scenarios. Cardiothoracic Surgeon 2020; 28(1): 15.
[http://dx.doi.org/10.1186/s43057-020-00025-0]
[9]
Joshi M, Kumar S, Noshirwani A, Harky A. The current management of cardiac tumours: A comprehensive literature review. Rev Bras Cir Cardiovasc 2020; 35(5): 770-80.
[http://dx.doi.org/10.21470/1678-9741-2019-0199] [PMID: 33118743]
[10]
Koo J, Knight-Perry J, Galambos C, Browne LP, Cost CR. Pediatric metastatic cardiac angiosarcoma successfully treated with multimodal therapy: Case report and review of literature. J Pediatr Hematol Oncol 2021; 43(2): e203-6.
[http://dx.doi.org/10.1097/MPH.0000000000001674] [PMID: 31725539]
[11]
Randhawa JS, Budd GT, Randhawa M, et al. Primary cardiac sarcoma. Am J Clin Oncol 2016; 39(6): 593-9.
[http://dx.doi.org/10.1097/COC.0000000000000106] [PMID: 25036471]
[12]
Bruce CJ. Cardiac tumours: Diagnosis and management. Heart 2011; 97(2): 151-60.
[http://dx.doi.org/10.1136/hrt.2009.186320] [PMID: 21163893]
[13]
Moradian M, Hejazi Zadeh B, Rashidi Ghader F, et al. Primary cardiac tumors in children: An 8-year-experience in a single center. Iran J Pediatr 2020; 30(6): 1-7.
[http://dx.doi.org/10.5812/ijp.108865]
[14]
Kocabaş A, Ekici F, Çetin İİ, et al. Cardiac rhabdomyomas associated with tuberous sclerosis complex in 11 children: presentation to outcome. Pediatr Hematol Oncol 2013; 30(2): 71-9.
[http://dx.doi.org/10.3109/08880018.2012.734896] [PMID: 23151153]
[15]
Jozwiak J. Hamartin and tuberin: Working together for tumour suppression. Int J Cancer 2006; 118(1): 1-5.
[http://dx.doi.org/10.1002/ijc.21542] [PMID: 16206276]
[16]
Maria BL. Tuberous sclerosis complex: Future research directions. J Child Neurol 2004; 19(9): 631-1.
[http://dx.doi.org/10.1177/08830738040190090101] [PMID: 15563007]
[17]
Chao AS, Chao A, Wang TH, et al. Outcome of antenatally diagnosed cardiac rhabdomyoma: Case series and a meta‐analysis. Ultrasound Obstet Gynecol 2008; 31(3): 289-95.
[http://dx.doi.org/10.1002/uog.5264] [PMID: 18307215]
[18]
Dimario FJ Jr, Diana D, Leopold H, Chameides L. Evolution of cardiac rhabdomyoma in tuberous sclerosis complex. Clin Pediatr 1996; 35(12): 615-9.
[http://dx.doi.org/10.1177/000992289603501202] [PMID: 8970753]
[19]
Stelmaszewski EV, Parente DB, Farina A, et al. Everolimus for cardiac rhabdomyomas in children with tuberous sclerosis. The ORACLE study protocol (everOlimus for caRdiac rhAbdomyomas in tuberous sCLErosis): a randomised, multicentre, placebocontrolled, double-blind phase II trial. Cardiol Young 2020; 30(3): 337-45.
[http://dx.doi.org/10.1017/S1047951119003147] [PMID: 31983379]
[20]
Sugalska M, Tomik A, Jóźwiak S, Werner B. Treatment of cardiac rhabdomyomas with mtor inhibitors in children with tuberous sclerosis complex-a systematic review. Int J Environ Res Public Health 2021; 18(9): 4907.
[http://dx.doi.org/10.3390/ijerph18094907] [PMID: 34062963]
[21]
Yuan SM. Fetal primary cardiac tumors during perinatal period. Pediatr Neonatol 2017; 58(3): 205-10.
[http://dx.doi.org/10.1016/j.pedneo.2016.07.004] [PMID: 28043830]
[22]
Corbacioglu Esmer A, Bornaun H, Turan Bakirci İ. Successful intrauterine treatment of nonimmune hydrops fetalis due to pericardial tumor. Marmara Medical Journal 2019; 32(2): 90-3.
[http://dx.doi.org/10.5472/marumj.570917]
[23]
Lyttle BD, Vaughn AE, Gallagher LT, et al. Successful open fetal resection of a pericardial teratoma: A case report. J Pediatr Surg Case Rep 2023; 96: 102696.
[http://dx.doi.org/10.1016/j.epsc.2023.102696]
[24]
Ritter AL, Granquist EJ, Iyer VR, Izumi K. Cardiac fibroma with ventricular tachycardia: An unusual clinical presentation of nevoid basal cell carcinoma syndrome. Mol Syndromol 2018; 9(4): 219-23.
[http://dx.doi.org/10.1159/000489056] [PMID: 30140199]
[25]
Pittman S, Sethi P, Flavell RR, Pampaloni MH. Cardiac fibroma. Clin Nucl Med 2018; 43(2): e56-8.
[http://dx.doi.org/10.1097/RLU.0000000000001924] [PMID: 29215416]
[26]
Rajput FA, Bishop MA, Limaiem F. Cardiac Fibroma 2022. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537081/
[27]
Isaacs H Jr. Fetal and neonatal cardiac tumors. Pediatr Cardiol 2004; 25(3): 252-73.
[http://dx.doi.org/10.1007/s00246-003-0590-4] [PMID: 15360117]
[28]
Mahilmaran A, Seshadri M, Nayar PG, Sudarsana G, Abraham KA. Familial cardiac myxoma: Carney’s complex. Tex Heart Inst J 2003; 30(1): 80-2.
[PMID: 12638680]
[29]
Kojima S, Sumiyoshi M, Watanabe Y, et al. A Japanese case of familial cardiac myxoma associated with a mutation of the PRKAR1α gene. Intern Med 2005; 44(6): 607-10.
[http://dx.doi.org/10.2169/internalmedicine.44.607] [PMID: 16020889]
[30]
Gošev I, Paić F, Đurić Ž, et al. Cardiac myxoma the great imitators: Comprehensive histopathological and molecular approach. Int J Cardiol 2013; 164(1): 7-20.
[http://dx.doi.org/10.1016/j.ijcard.2011.12.052] [PMID: 22243936]
[31]
Yuan SM. Fetal Cardiac Myxomas. Z Geburtshilfe Neonatol 2017; 221(4): 175-9.
[http://dx.doi.org/10.1055/s-0043-115228] [PMID: 28800669]
[32]
Killion E, Mohan K, Lee E. A review of vascular anomalies: genetics and common syndromes. Semin Plast Surg 2014; 28(2): 064-8.
[http://dx.doi.org/10.1055/s-0034-1376261] [PMID: 25045331]
[33]
Tongsong T, Sirichotiyakul S, Sittiwangkul R, Wanapirak C. Prenatal sonographic diagnosis of cardiac hemangioma with postnatal spontaneous regression. Ultrasound Obstet Gynecol 2004; 24(2): 207-8.
[http://dx.doi.org/10.1002/uog.1102] [PMID: 15287062]
[34]
Ottaviani G, Matturri L, Rossi L, Lavezzi AM, James TN. Multifocal cardiac Purkinje cell tumor in infancy. Europace 2004; 6(2): 138-41.
[http://dx.doi.org/10.1016/j.eupc.2003.10.002] [PMID: 15018873]
[35]
Rossi L, Piffer R, Turolla E, Frigerio B, Coumel P, James TN. Multifocal Purkinje-like tumor of the heart. Occurrence with other anatomic abnormalities in the atrioventricular junction of an infant with junctional tachycardia, Lown-Ganong-Levine syndrome, and sudden death. Chest 1985; 87(3): 340-5.
[http://dx.doi.org/10.1378/chest.87.3.340] [PMID: 3971758]
[36]
Amano J, Nakayama J, Yoshimura Y, Ikeda U. Clinical classification of cardiovascular tumors and tumor-like lesions, and its incidences. Gen Thorac Cardiovasc Surg 2013; 61(8): 435-47.
[http://dx.doi.org/10.1007/s11748-013-0214-8] [PMID: 23460447]
[37]
Malhotra V, Ferrans VJ, Virmani R. Infantile histiocytoid cardiomyopathy: Three cases and literature review. Am Heart J 1994; 128(5): 1009-21.
[http://dx.doi.org/10.1016/0002-8703(94)90601-7] [PMID: 7942464]
[38]
Mahani MG, Lu JC, Rigsby CK, Krishnamurthy R, Dorfman AL, Agarwal PP. MRI of pediatric cardiac masses. AJR Am J Roentgenol 2014; 202(5): 971-81.
[http://dx.doi.org/10.2214/AJR.13.10680] [PMID: 24758649]
[39]
Yadava OP. Cardiac tumours in infancy. Indian Heart J 2012; 64(5): 492-6.
[http://dx.doi.org/10.1016/j.ihj.2012.05.004] [PMID: 23102388]
[40]
Tzani A, Doulamis IP, Mylonas KS, Avgerinos DV, Nasioudis D. Cardiac tumors in pediatric patients: A systematic review. World J Pediatr Congenit Heart Surg 2017; 8(5): 624-32.
[http://dx.doi.org/10.1177/2150135117723904] [PMID: 28901236]

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