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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Antitumor Effects of Curcumin on Cervical Cancer with the Focus on Molecular Mechanisms: An Exegesis

Author(s): Ali Govahi, Neda Zahmatkesh, Omid Pourbagherian, Neda Maleki Khas, Tala Salamzadeh, Hasti Moshtagh Mehr, Esmaeil Babaei* and Mahsa Hajivalili*

Volume 29, Issue 42, 2023

Published on: 08 December, 2023

Page: [3385 - 3399] Pages: 15

DOI: 10.2174/0113816128279330231129180250

Price: $65


Cervical cancer is one of the most prevalent malignancies among females and is correlated with a significant fatality rate. Chemotherapy is the most common treatment for cervical cancer; however, it has a low success rate due to significant side effects and the incidence of chemo-resistance. Curcumin, a polyphenolic natural compound derived from turmeric, acts as an antioxidant by diffusing across cell membranes into the endoplasmic reticulum, mitochondria, and nucleus, where it performs its effects. As a result, it's been promoted as a chemo-preventive, anti-metastatic, and anti-angiogenic agent. As a consequence, the main goal of the present review was to gather research information that looked at the link between curcumin and its derivatives against cervical cancer.

Keywords: Curcumin, cervical cancer, herbal remedy, curcumin limitation, curcumin nanoparticles, Curcuma longa.

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