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Anti-Cancer Agents in Medicinal Chemistry


ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Review Article

CRD-BP as a Tumor Marker of Colorectal Cancer

Author(s): Fen-Xu, Liang-Hong Jiang, Chen-Fu, Wei-Wei Feng and Chang-Jiang Zhou*

Volume 24, Issue 3, 2024

Published on: 21 November, 2023

Page: [169 - 176] Pages: 8

DOI: 10.2174/0118715206256546231108095912

Price: $65


The National Cancer Center published a comparative report on cancer data between China and the United States in the Chinese Medical Journal, which shows that colorectal cancer (CRC) ranks second in China and fourth in the United States. It is worth noting that since 2000, the case fatality rate of CRC in China has skyrocketed, while the United States has gradually declined. Finding tumor markers with high sensitivity and specificity is our primary goal to reduce the case fatality rate of CRC. Studies have shown that CRD-BP (Insulin-like growth factor 2 mRNA-binding protein 1) can affect a variety of signaling pathways, such as Wntnuclear factor KB (NF-κB), and Hedgehog, and has good biological effects as a therapeutic target for CRC. CRD-BP is expected to become a tumor marker with high sensitivity and specificity of CRC. This paper reviews the research on CRD-BP as a tumor marker of CRC.

Keywords: CRD-BP, signal path, colorectal cancer, tumor marker, mRNA, β-catenin.

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