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Current Psychiatry Research and Reviews

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ISSN (Print): 2666-0822
ISSN (Online): 2666-0830

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Clinical Trial

Investigating the Effect of Ginger as an Adjunctive Treatment along with SSRIs to Reduce Anxiety in Patients with GAD: A Clinical Trial Study

Author(s): Sara Ataei, Leila Jahangard, Sina Anaraki*, Dara Dastan and Salman Khazaei

Volume 21, Issue 2, 2025

Published on: 02 November, 2023

Page: [177 - 185] Pages: 9

DOI: 10.2174/0126660822258340231025171755

Price: $65

Abstract

Introduction: Generalized anxiety disorder (GAD) is characterized by exaggerated anxiety without any apparent cause of concern. The primary treatment of this disorder is usually SSRIs, which have many digestive side effects and do not provide complete treatment for the patient. The use of non-pharmacological methods may help reduce these complications. Therefore, the present study was conducted to investigate the effect of ginger as an adjunctive therapy along with SSRIs to reduce anxiety in patients with GAD.

Materials and Methods: In this double-blind, controlled clinical trial study, a total of 80 patients with GAD were randomly assigned into two groups. For the intervention group, at the same time as SSRI drug, two 500-mg ginger capsules were used daily while in the control group, two starch capsules were used daily as a placebo along with SSRI. Data collection tools were Hamilton's anxiety questionnaire and a gastrointestinal symptom severity scale. Data were collected before the intervention and after the 12-week intervention.

Results: There was no significant difference between the intervention and control groups in terms of average anxiety and severity of digestive symptoms before the intervention (p > 0.05), but there was a significant difference between the groups after the intervention (p < 0.05). Also, the average scores of anxiety and severity of gastrointestinal symptoms in the intervention group increased significantly from the beginning of the intervention to the follow-up (intragroup difference) (p < 0.05).

Conclusion: The results of the study showed that the use of ginger along with SSRIs reduced anxiety and released the severity of gastrointestinal symptoms in patients with GAD. In addition, in this study, it was found that ginger, along with SSRIs, can have beneficial effects on indigestion, diarrhea, and nausea in patients with GAD. However, these findings require more extensive research.

Keywords: Ginger, SSRI, generalized anxiety disorder, gastrointestinal symptoms, adjunctive treatment, Zingiber officinale.

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[1]
Ruscio, A.M.; Hallion, L.S.; Lim, C.C.W.; Aguilar-Gaxiola, S.; Al-Hamzawi, A.; Alonso, J. Cross-sectional Comparison of the Epidemiology of DSM-5 GAD Across the Globe. JAMA Psychiatry, 2017, 74(5), 465-475.
[http://dx.doi.org/10.1001/jamapsychiatry.2017.0056] [PMID: 28297020]
[2]
Terlizzi, E.P.; Villarroel, M.A. Symptoms of Generalized Anxiety Disorder Among Adults: United States, 2019. NCHS Data Brief, 2020, 378, 1-8.
[3]
Fayazbakhsh, E.; Mansouri, A. Effectiveness of acceptance and commitment therapy on intolerance of uncertainty, experiential avoidance, and symptoms of GAD in individuals with Type II diabetes. International Archives of Health Sciences, 2019, 6(1), 30.
[http://dx.doi.org/10.4103/iahs.iahs_52_18]
[4]
Bandelow, B.; Michaelis, S.; Wedekind, D. Treatment of anxiety disorders. Dialogues Clin. Neurosci., 2017, 19(2), 93-107.
[PMID: 28867934]
[5]
Bandelow, B.; Werner, A.M.; Kopp, I.; Rudolf, S.; Wiltink, J.; Beutel, M.E. The German Guidelines for the treatment of anxiety disorders: First revision. Eur. Arch. Psychiatry Clin. Neurosci., 2022, 272(4), 571-582.
[http://dx.doi.org/10.1007/s00406-021-01324-1] [PMID: 34609587]
[6]
Elvir-Lazo, O.L.; White, P.F.; Cruz Eng, H.; Yumul, F.; Chua, R.; Yumul, R. Impact of chronic medications in the perioperative period: Mechanisms of action and adverse drug effects (Part I). Postgrad. Med., 2021, 133(8), 939-952.
[http://dx.doi.org/10.1080/00325481.2021.1982297] [PMID: 34551662]
[7]
Li, H.; Liu, Y.; Luo, D. Ginger for health care: An overview of systematic reviews. Complement. Ther. Med., 2019, 45, 114-123.
[http://dx.doi.org/10.1016/j.ctim.2019.06.002] [PMID: 31331547]
[8]
Bashir, F.; Afrin, Z. Zanjabeel (Zingiber offcinale) Transformation of Culinary Spice to a multi-functional Medicine. J. Drug Deliv. Ther., 2019, 9(4-s), 721-725.
[http://dx.doi.org/10.22270/jddt.v9i4-s.3299]
[9]
Nievergelt, A.; Huonker, P.; Schoop, R.; Altmann, K.H.; Gertsch, J. Identification of serotonin 5-HT1A receptor partial agonists in ginger. Bioorg. Med. Chem., 2010, 18(9), 3345-3351.
[http://dx.doi.org/10.1016/j.bmc.2010.02.062] [PMID: 20363635]
[10]
Clark, D.B.; Donovan, J. Reliability and validity of the Hamilton Anxiety Rating Scale in an adolescent sample. J. Am. Acad. Child Adolesc. Psychiatry, 1994, 33(3), 354-360.
[http://dx.doi.org/10.1097/00004583-199403000-00009] [PMID: 8169180]
[11]
Revicki, D.A.; Wood, M.; Wiklund, I.; Crawley, J. Reliability and validity of the Gastrointestinal Symptom Rating Scale in patients with gastroesophageal reflux disease. Qual. Life Res., 1997, 7(1), 75-83.
[http://dx.doi.org/10.1023/A:1008841022998] [PMID: 9481153]
[12]
Mazaheri, M. Comparison between psychometric characteristics of persian version of the gastrointestinal symptoms rating scale in functional gastrointestinal disorders and normal groups. Govaresh, 2012, 17(1), 18-24.
[13]
Rahmani, M.; Zanjani, Z.; Omidi, A. The Mediating Role of Cognitive Emotion Regulation and Mindfulness in the Relationship Between Worry and Generalized Anxiety. J. Arak Univ. Med. Sci., 2022, 25(1), 142-155.
[http://dx.doi.org/10.32598/jams.25.1.6730.1]
[14]
Roberge, P.; Normand-Lauzière, F.; Raymond, I.; Luc, M.; Tanguay-Bernard, M.M.; Duhoux, A. GAD in primary care: Mental health services use and treatment adequacy. BMC Fam. Pract., 2015, 16, 146.
[http://dx.doi.org/10.1186/s12875-015-0358-y] [PMID: 26492867]
[15]
Grenier, S.; Desjardins, F.; Raymond, B.; Payette, M.C.; Rioux, M.; Landreville, P. Six-month prevalence and correlates of GAD among primary care patients aged 70 years and above: Results from the ESA-services study. Int. J. Geriatr. Psychiatry, 2019, 34(2), 315-323.
[http://dx.doi.org/10.1002/gps.5023] [PMID: 30418683]
[16]
Leonard, K.; Abramovitch, A. Cognitive functions in young adults with GAD. Eur. Psychiatry, 2019, 56, 1-7.
[http://dx.doi.org/10.1016/j.eurpsy.2018.10.008] [PMID: 30458333]
[17]
O’Brien, K.; O’Keeffe, N.; Cullen, H.; Durcan, A.; Timulak, L.; McElvaney, J. Emotion-focused perspective on GAD: A qualitative analysis of clients’ in-session presentations. Psychother. Res., 2019, 29(4), 524-540.
[http://dx.doi.org/10.1080/10503307.2017.1373206] [PMID: 28893153]
[18]
Sihombing, A.T.; Prabharani, D.; Lukman, K.; Sudjud, R.W. The effectiveness of ginger extract addition in calorified drinks during perioperative period to nausea severity, vomitus, post-operative anxiety, and metabolic disorder: A randomized control trial. Ann. Med. Surg. (Lond.), 2022, 84104865.
[http://dx.doi.org/10.1016/j.amsu.2022.104865] [PMID: 36536711]
[19]
Jiang, F.; Kobayashi, T.; Ichihashi, T.; Ito, K.; Nomura, S. The effect of citrus ginger aroma on heart rate and salivary cortisol level during sleep at home. IEEJ Trans. Electr. Electron. Eng., 2019, 14(4), 623-629.
[http://dx.doi.org/10.1002/tee.22845]
[20]
Machado-Vieira, R.; Baumann, J.; Wheeler-Castillo, C. The Timing of Antidepressant Effects: A Comparison of Diverse Pharmacological and Somatic Treatments. Pharmaceuticals (Basel), 2010, 3(1), 19-41.
[http://dx.doi.org/10.3390/ph3010019] [PMID: 27713241]
[21]
Rostamkhani, M.; Khosravi, S.; Rezaie, K.; Forozan, A.; Rafiei, F. The effect of ginger on the symptoms of irritable bowel syndrome: A randomized clinical trial. J. Med. Plants, 2018, 17(68), 112-121.
[22]
Giacosa, A.; Guido, D.; Grassi, M. The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial. Evid. Based Complement. Alternat. Med., 2015, 2015, 1-9.
[http://dx.doi.org/10.1155/2015/915087] [PMID: 25954317]
[23]
Nikkhah Bodagh, M.; Maleki, I.; Hekmatdoost, A. Ginger in gastrointestinal disorders: A systematic review of clinical trials. Food Sci. Nutr., 2019, 7(1), 96-108.
[http://dx.doi.org/10.1002/fsn3.807] [PMID: 30680163]
[24]
Tavlan, A.; Tuncer, S.; Erol, A.; Reisli, R.; Aysolmaz, G.; Otelcioglu, S. Prevention of postoperative nausea and vomiting after thyroidectomy: Combined antiemetic treatment with dexamethasone and ginger versus dexamethasone alone. Clin. Drug Investig., 2006, 26(4), 209-214.
[http://dx.doi.org/10.2165/00044011-200626040-00005] [PMID: 17163253]
[25]
Blumenthal, M. Ginger as an antiemetic during pregnancy. Altern. Ther. Health Med., 2003, 9(1), 19-21.
[PMID: 12564347]
[26]
Kiuchi, F.; Shibuya, M.; Sankawa, U. Inhibitors of prostaglandin biosynthesis from ginger. Chem. Pharm. Bull. (Tokyo), 1982, 30(2), 754-757.
[http://dx.doi.org/10.1248/cpb.30.754] [PMID: 7094159]

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