Quercetin and Its Derivatives: Synthesis, Pharmacological Uses with Special Emphasis on Anti-Tumor Properties and Prodrug with Enhanced Bio-Availability

Title: Quercetin and Its Derivatives: Synthesis, Pharmacological Uses with Special Emphasis on Anti-Tumor Properties and Prodrug with Enhanced Bio-Availability

Volume: 9 Issue: 2

Author(s): Ketan V. Hirpara, Pawan Aggarwal, Amrita J. Mukherjee, Narendra Joshi and Anand C. Burman

Affiliation:

Keywords: Anticancer, flavanoid, glycoside, quercetin, QC12, synthesis

Abstract: Cancer is one of the leading causes of death in the world. American Cancer Society reported 12 million new cases of malignancy diagnosed worldwide in 2007, with 7.6 million people dying from the disease. Plant-derived molecules have played an important role in cancer chemotherapy. Many cytotoxic plant-derived molecules such as vinblastine, vincristine, navelbine, etoposide, teniposide, taxol, taxotere, topotecan and irinotecan have been approved as anticancer drugs. Flavonoids, a plant-derived molecule has shown to regulate proliferation and cell death pathways leading to cancer. Some Flavonoids have already entered in clinical trials, among them Quercetin is emerging as prospective anticancer drug candidates and its prodrug QC12 has entered in phase-I clinical studies. In this review authors have tried to cover in brief but comprehensive way, the chemistry related to synthesis and uses of “Quercetin & its derivatives” with special emphasis on the anticancer properties.

Cite this article as:

Hirpara V. Ketan, Aggarwal Pawan, Mukherjee J. Amrita, Joshi Narendra and Burman C. Anand, Quercetin and Its Derivatives: Synthesis, Pharmacological Uses with Special Emphasis on Anti-Tumor Properties and Prodrug with Enhanced Bio-Availability, Anti-Cancer Agents in Medicinal Chemistry 2009; 9(2) . https://dx.doi.org/10.2174/187152009787313855