An Overview of the Pharmacological Properties of Calebin-A

Title:An Overview of the Pharmacological Properties of Calebin-A

Volume: 31

Author(s): Hedieh Shamsnia, Amirreza Samanian, Ayeh Sabbagh Kashani, Danial Khayatan, Saeideh Momtaz, Thomas P. Johnston, Muhammed Majeed, Tannaz Jamialahmadi, Amir Hossein Abdolghaffari and Amirhossein Sahebkar*

Affiliation:

• Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
• Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Keywords: Polyphenol, Calebin-A, curcumin, turmeric, pharmacology, phytochemical

Abstract: The natural polyphenol, calebin-A, was recently discovered and identified as a novel phytopharmaceutical with anti-inflammatory, anti-tumor, and antiproliferative properties. Calebin-A occurs naturally in trace quantities in Curcuma longa/C cassia, commonly known as turmeric, from the Zingiberaceae family. Calebin-A is a curcumin analog or 'chemical cousin' of curcumin with a similar chemical structure. Although few research studies have been conducted on the pharmacological and therapeutic properties of calebin-A, it is a very promising molecule with a variety of pharmacological properties. Some studies have suggested that calebin-A is helpful in treating various cancers due to its inhibitory effect on cell growth and anti-inflammatory properties. Other studies have suggested that calebin-A may improve neurocognitive status associated with neurodegeneration caused by Alzheimer’s disease (AD) by inhibiting the aggregation of β-amyloid. Finally, several studies have proposed that calebin-A may potentially be therapeutically beneficial in treating patients with obesity. This novel compound downregulates nuclear factor (NF)-κB-mediated processes involved with cancer, such as tumor cell invasion, proliferation, metastasis, and, most profoundly, inflammation. Moreover, calebin-A influences the activities of mitogen-activated protein kinases (MAPKs) in cancer cells. The present review identifies and discusses the pharmacological and phytochemical properties of calebin-A, as well as its therapeutic benefits and limitations, for future scientists and clinicians interested in exploring calebin-A’s medicinal qualities.

Cite this article as:

Shamsnia Hedieh, Samanian Amirreza, Sabbagh Kashani Ayeh, Khayatan Danial, Momtaz Saeideh, Johnston P. Thomas, Majeed Muhammed, Jamialahmadi Tannaz, Abdolghaffari Hossein Amir and Sahebkar Amirhossein*, An Overview of the Pharmacological Properties of Calebin-A, Current Medicinal Chemistry 2024; 31 () . https://dx.doi.org/10.2174/0109298673245074230925153031