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Combinatorial Chemistry & High Throughput Screening


ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Using Electrospray Ionisation Mass Spectrometry to Study Non-Covalent Interactions

Author(s): Bryan J. McCullough and Simon J. Gaskell

Volume 12, Issue 2, 2009

Page: [203 - 211] Pages: 9

DOI: 10.2174/138620709787315463

Price: $65


The key strengths of electrospray over any other ionisation techniques are its soft nature and its ability to produce multiply charged ions. This combination is ideal for the study of non-covalent interactions. In this review article, we cover the basics of studying non-covalent interactions by mass spectrometry - illustrated with examples from our own and other labs - and discuss the current mass spectrometry based methods used for understanding and characterising noncovalent protein complexes.

Keywords: Mass Spectrometry, Electrospray Ionisation, Non-Covalent Interactions, ESI mass spectrum, PROTEIN-LIGAND INTERACTIONS

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