Generic placeholder image

Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Designer Peptides: Learning from Nature

Author(s): A. Shrivastava, A. D. Nunn and M. F. Tweedle

Volume 15, Issue 6, 2009

Page: [675 - 681] Pages: 7

DOI: 10.2174/138161209787315620

Price: $65


Recent advances in designing peptide ligands for therapeutic targets are making peptides an attractive alternative to small molecules and proteins. It is now common to see peptides developed with affinities comparable to antibodies and specificities much better than small molecules or antibodies. This is especially true in the case of tumor targeting cytotoxic drugs or targeted diagnostics where peptides can be used as a delivery vehicle for drugs or diagnostics. Moreover, lessons learned from nature in understanding peptide ligands are proving to be useful in designing better antibodies and small molecule therapeutics.

Keywords: c-MET, HMPs, heterodimer, peptide, VEGFR-2, antibody, small molecule, targeted drugs

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy