Abstract
The laboratory rat is obviously an important model for physiology, pathology, pharmacology, toxicology, and transplantation experiments. The value for pharmacological research is immense since virtually every drug approved for human treatment passes through the body of laboratory rats. Hundreds of unique rat models have been developed to mimic pathological and physiological human clinical conditions, especially in the case of complex diseases. Many of the model rats are deposited into rat resource centers, from which researchers can use and share animals and rat related resources in biomedical research. Recent progressing technologies for genetically engineered rats, such as traditional transgenesis, chemical ENU mutagenesis, and transposon insertional mutagenesis, wil l provide thousands of useful rat models for functional genomics and human diseases. Globally acting rat resource centers are prerequisites for successful and sustainable research in the biomedical field where the rats are used as model species.
Keywords: biomedical research, model species, laboratory rats, complex, transgenesis
Current Pharmaceutical Biotechnology
Title: Rat Resources in Biomedical Research
Volume: 10 Issue: 2
Author(s): Tomoji Mashimo and Tadao Serikawa
Affiliation:
Keywords: biomedical research, model species, laboratory rats, complex, transgenesis
Abstract: The laboratory rat is obviously an important model for physiology, pathology, pharmacology, toxicology, and transplantation experiments. The value for pharmacological research is immense since virtually every drug approved for human treatment passes through the body of laboratory rats. Hundreds of unique rat models have been developed to mimic pathological and physiological human clinical conditions, especially in the case of complex diseases. Many of the model rats are deposited into rat resource centers, from which researchers can use and share animals and rat related resources in biomedical research. Recent progressing technologies for genetically engineered rats, such as traditional transgenesis, chemical ENU mutagenesis, and transposon insertional mutagenesis, wil l provide thousands of useful rat models for functional genomics and human diseases. Globally acting rat resource centers are prerequisites for successful and sustainable research in the biomedical field where the rats are used as model species.
Export Options
About this article
Cite this article as:
Mashimo Tomoji and Serikawa Tadao, Rat Resources in Biomedical Research, Current Pharmaceutical Biotechnology 2009; 10 (2) . https://dx.doi.org/10.2174/138920109787315105
DOI https://dx.doi.org/10.2174/138920109787315105 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
Latest Advancements in Biotherapeutics.
The scope of this thematic issue is to comprehensively explore the rapidly evolving landscape of biotherapeutics, emphasizing breakthroughs in precision medicine. Encompassing diverse therapeutic modalities, the issue will delve into the latest developments in monoclonal antibodies, CRISPR/Cas gene editing, CAR-T cell therapies, and innovative drug delivery systems, such as nanoparticle-based ...read more
Machine Learning and Artificial Intelligence for Medical Data Analysis and Human Information Analysis in Healthcare
The intersection of machine learning (ML) and artificial intelligence (AI) with the pharmaceutical industry is revolutionizing traditional paradigms in drug discovery and development. These technologies have introduced innovative approaches to analyzing complex datasets and predicting chemical properties, leading to more efficient identification and optimization of drug candidates. By employing sophisticated ...read more

- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Recent Development in Substituted Benzothiazole as an Anticonvulsant Agent
Mini-Reviews in Medicinal Chemistry A Review on <i>Valeriana wallichii</i>: Chemical Composition and Pharmacological Research
Current Traditional Medicine Erythropoietin and mTOR: A “One-Two Punch” for Aging-Related Disorders Accompanied by Enhanced Life Expectancy
Current Neurovascular Research Controlled Somatic and Germline Copy Number Variation in the Mouse Model
Current Genomics Nanomaterials for Neurology: State-of-the-Art
CNS & Neurological Disorders - Drug Targets Editorial
Drug Delivery Letters Tools in the Design of Therapeutic Drugs for CNS Disorders: An up-to-date Review
Current Molecular Pharmacology Isoniazid Induced Convulsions at Therapeutic Dose in an Alcoholic and Smoker Patient
Current Drug Safety Z-Acrylonitrile Derivatives: Improved Synthesis, X-ray Structure, and Interaction with Human Serum Albumin
Current Organic Synthesis Neurogenic Drugs and Compounds
Recent Patents on CNS Drug Discovery (Discontinued) Metabolic Inhibitors as Antiparasitic Drugs: Pharmacological, Biochemical and Molecular Perspectives
Current Drug Metabolism Antitumor Potential and Possible Targets of Phenothiazine-Related Compounds
Current Drug Targets Novel Insights into V-ATPase Functioning: Distinct Roles for its Accessory Subunits ATP6AP1/Ac45 and ATP6AP2/(pro) Renin Receptor
Current Protein & Peptide Science Drug Development for Central Nervous System Diseases Using In vitro Blood-brain Barrier Models and Drug Repositioning
Current Pharmaceutical Design Pharmacokinetic Interactions Between Antiseizure and Psychiatric Medications
Current Neuropharmacology PET with Non-Standard Nuclides
Current Topics in Medicinal Chemistry Advanced Platelet-Rich Fibrin Extract Treatment Promotes the Proliferation and Differentiation of Human Adipose-Derived Mesenchymal Stem Cells through Activation of Tryptophan Metabolism
Current Stem Cell Research & Therapy Neurodegeneration and Neurogenesis: Focus on Alzheimers Disease
Current Alzheimer Research Fibromyalgia: Mechanisms, Current Treatment and Animal Models
Current Pharmaceutical Biotechnology Importance of P-gp PET Imaging in Pharmacology
Current Pharmaceutical Design