Targeting the Tumor Stroma in Cancer Therapy

Title: Targeting the Tumor Stroma in Cancer Therapy

Volume: 10 Issue: 2

Author(s): Kevin Anton and John Glod

Affiliation:

Keywords: Tumor Stroma, Cancer Therapy, neoplastic cells, lymphocytes, vascular cells, angiogenesis

Abstract: Increasing evidence shows that the interaction between neoplastic cells and the surrounding stroma is a critical factor in solid tumor growth. The tumor stroma is made up of diverse cellular populations including macrophages, lymphocytes, vascular cells, and carcinoma-associated fibroblasts. The complex interactions between the stroma and neoplastic cells are largely unexplored. Initial therapies aimed at disrupting angiogenesis within the tumor microenvironment have met with success in a number of tumor types. An improved understanding of stromal signaling pathways is likely to identify additional novel therapeutic targets.

Cite this article as:

Anton Kevin and Glod John, Targeting the Tumor Stroma in Cancer Therapy, Current Pharmaceutical Biotechnology 2009; 10 (2) . https://dx.doi.org/10.2174/138920109787315088