Abstract
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease marked by inflammation of synovium and generation of autoantibodies. Bone and cartilage are frequently damaged along with weakening of tendons and ligaments resulting in disability. An effective RA treatment needs a multi-disciplinary approach which relies upon pathophysiology that is still partially understood. In RA patients, inflammation was induced by pro-inflammatory cytokines including IL-1, IL-6 & IL-10. The conventional dosage regimens for treating RA have drawbacks such as ineffectiveness, greater doses, frequent dosing, relatively expensive and serious adverse effects. To formulate an effective treatment plan for RA, research teams have recently focused on producing several nanoformulations containing anti-inflammatory APIs with an aim to target the inflamed area. Nanomedicines have recently gained popularity in the treatment of RA. Interestingly, unbelievable improvements have been observed in current years in diagnosis and management of RA utilizing nanotechnology. Various patents and clinical trial data have been reported in relevance to RA treatment.
Keywords: Rheumatoid arthritis, anti-inflammatory, nano-based therapeutics, nanoformulations, cytokines, nanomedicines.
Recent Patents on Nanotechnology
Title:Nano-based Therapeutics for Rheumatoid Arthritis: Recent Patents and Development
Volume: 19 Issue: 1
Author(s): Manish Makhija, Deeksha Manchanda and Manu Sharma*
Affiliation:
- Department of Pharmacy, Banasthali Vidyapith, Rajasthan, 304022, India
Keywords: Rheumatoid arthritis, anti-inflammatory, nano-based therapeutics, nanoformulations, cytokines, nanomedicines.
Abstract: Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease marked by inflammation of synovium and generation of autoantibodies. Bone and cartilage are frequently damaged along with weakening of tendons and ligaments resulting in disability. An effective RA treatment needs a multi-disciplinary approach which relies upon pathophysiology that is still partially understood. In RA patients, inflammation was induced by pro-inflammatory cytokines including IL-1, IL-6 & IL-10. The conventional dosage regimens for treating RA have drawbacks such as ineffectiveness, greater doses, frequent dosing, relatively expensive and serious adverse effects. To formulate an effective treatment plan for RA, research teams have recently focused on producing several nanoformulations containing anti-inflammatory APIs with an aim to target the inflamed area. Nanomedicines have recently gained popularity in the treatment of RA. Interestingly, unbelievable improvements have been observed in current years in diagnosis and management of RA utilizing nanotechnology. Various patents and clinical trial data have been reported in relevance to RA treatment.
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Cite this article as:
Makhija Manish, Manchanda Deeksha and Sharma Manu*, Nano-based Therapeutics for Rheumatoid Arthritis: Recent Patents and Development, Recent Patents on Nanotechnology 2025; 19 (1) . https://dx.doi.org/10.2174/1872210518666230905155459
DOI https://dx.doi.org/10.2174/1872210518666230905155459 |
Print ISSN 1872-2105 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4020 |
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