Abstract
The natriuretic peptides (NP) appear to be functional by midgestation, respond to volume stimuli, and regulate blood pressure and salt and water balance in the developing embryo. In addition, the NP may help regulate the blood supply to the fetus, acting as vasodilators in the placental vasculature. Peaks of ANP and BNP expression during gestation coincide with significant events in cardiac organogenesis, suggesting a role for NP in the formation of the heart. Levels of atrial natriuretic peptide (ANP) are higher in the fetal circulation than in adults, and fetal ventricles express higher levels of ANP and B-type natriuretic peptide (BNP) than adult ventricles. In this comprehensive review we have discussed the role NP during development of the fetal heart and circulation and in various cardiovascular diseases of neonatal and pediatric age group.
Keywords: Natriuretic peptides, ANP, BNP, NT-proBNP, CNP
Cardiovascular & Hematological Agents in Medicinal Chemistry
Title: Natriuretic Peptides in Cardiovascular Diseases of Fetus, Infants and Children
Volume: 7 Issue: 1
Author(s): Bibhuti B. Das, Shashi Raj and Robert Solinger
Affiliation:
Keywords: Natriuretic peptides, ANP, BNP, NT-proBNP, CNP
Abstract: The natriuretic peptides (NP) appear to be functional by midgestation, respond to volume stimuli, and regulate blood pressure and salt and water balance in the developing embryo. In addition, the NP may help regulate the blood supply to the fetus, acting as vasodilators in the placental vasculature. Peaks of ANP and BNP expression during gestation coincide with significant events in cardiac organogenesis, suggesting a role for NP in the formation of the heart. Levels of atrial natriuretic peptide (ANP) are higher in the fetal circulation than in adults, and fetal ventricles express higher levels of ANP and B-type natriuretic peptide (BNP) than adult ventricles. In this comprehensive review we have discussed the role NP during development of the fetal heart and circulation and in various cardiovascular diseases of neonatal and pediatric age group.
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Das B. Bibhuti, Raj Shashi and Solinger Robert, Natriuretic Peptides in Cardiovascular Diseases of Fetus, Infants and Children, Cardiovascular & Hematological Agents in Medicinal Chemistry 2009; 7 (1) . https://dx.doi.org/10.2174/187152509787047667
DOI https://dx.doi.org/10.2174/187152509787047667 |
Print ISSN 1871-5257 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6182 |
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