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Current Cardiology Reviews


ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

Renin Angiotensin System as a Regulator of Cell Volume. Implications to Myocardial Ischemia

Author(s): Walmor C. De Mello

Volume 5, Issue 1, 2009

Page: [65 - 68] Pages: 4

DOI: 10.2174/157340309787048149

Price: $65


It is known that long lasting changes in cell volume are incompatible with cellular functions. In the present review, I discussed the role of cell volume on gene expression and protein synthesis as well as the importance of the renin angiotensin system on the regulation of cell volume in the failing heart. Moreover, the relationship between mechanical stretch, cell volume and the renin angiotensin system as well some translational studies are also described and their relevance to the prevention or reduction of cardiac damage during myocardial ischemia is emphasized.

Keywords: Cell volume, myocardial ischemia, renin, angiotensin II, angiotensin (1-7) intracrine, stretch

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