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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Non-oxidative Modified Low-density Lipoproteins: The Underappreciated Risk Factors for Atherosclerosis

In Press, (this is not the final "Version of Record"). Available online 22 September, 2023
Author(s): Yimeng Zhao, Qian Xu, Naiqi He, Mulin Jiang, Yingzhuo Chen, Zhong Ren, Zhihan Tang, Chunyan Wu and Lushan Liu*
Published on: 22 September, 2023

DOI: 10.2174/0929867331666230807154019

Price: $95


Atherosclerosis, the pathological basis of most cardiovascular diseases, is a main risk factor causing about 20 million deaths each year worldwide. Oxidized low-density lipoprotein is recognized as the most important and independent risk factor in initiating and promoting atherosclerosis. Numerous antioxidants are extensively used in clinical practice, but they have no significant effect on reducing the morbidity and mortality of cardiovascular diseases. This finding suggests that researchers should pay more attention to the important role of non-oxidative modified low-density lipoprotein in atherosclerosis with a focus on oxidized low-density lipoprotein. This review briefly summarizes several important non-oxidative modified low-density lipoproteins associated with atherosclerosis, introduces the pathways through which these non-oxidative modified low-density lipoproteins induce the development of atherosclerosis in vivo, and discusses the mechanism of atherogenesis induced by these non-oxidative modified low-density lipoproteins. New therapeutic strategies and potential drug targets are provided for the prevention and treatment of atherosclerotic cardiovascular diseases.

Keywords: Atherosclerosis, non-oxidative modified LDLs, nitrated LDL, carbamylated LDL, glycated LDL, lipoproteins.

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