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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Drug Repurposing against Novel Therapeutic Targets in Plasmodium falciparum for Malaria: The Computational Perspective

In Press, (this is not the final "Version of Record"). Available online 25 September, 2023
Author(s): Shweta Rai, Shruti Shukla, Luciana Scotti and Ashutosh Mani*
Published on: 25 September, 2023

DOI: 10.2174/0929867331666230807151708

Price: $95

Abstract

Malaria remains one of the most challenging tropical diseases. Since malaria cases are reportedly alarming in terms of infections and mortality, urgent attention is needed for addressing the issues of drug resistance in falciparum malaria. High throughput screening methods have paved way for rapid identification of anti-malarial. Furthermore, drug repurposing helps in shortening the time required for drug safety approvals. Hence, discovery of new antimalarials by drug repurposing is a promising approach for combating the disease. This article summarizes the recent computational approaches used for identifying novel antimalarials by using drug target interaction tools followed by pharmacokinetic studies.

Keywords: Falciparum, antimalarial, drug repurposing, computational biology, tropical diseases, computational perspective


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