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Infectious Disorders - Drug Targets


ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Review Article

Current Leads and Marketed Formulations for an Effective Treatment of Fungal Infections

Author(s): Trambak Basak and Amit K. Goyal*

Volume 23, Issue 8, 2023

Published on: 10 August, 2023

Article ID: e260723219097 Pages: 14

DOI: 10.2174/1871526523666230726114855

Price: $65


Severe antifungal infections, especially opportunistic fungal infections, are increasing tremendously in immunocompromised patients. This is basically because more patients enduring neoplastic diseases lead to the wide use of chemotherapy, thus causing immunosuppression. Patients with HIV infection, burns, pancreatitis and neutropenia are also amenable to fungal infections. Out of a plethora of antifungal drugs applied, Amphotericin B, being a broad-spectrum antimicrobial drug, has been the gold standard treatment for a diverse variety of fungal infections since the 1950s and visceral leishmaniasis since the 1960s. However, Amphotericin B has major constraints of poor bioavailability and kidney toxicity, due to which newer antifungal compounds are being used. This article discusses fungal and parasitic diseases and formulations for treating these ailments.

Keywords: Fungal infections, amphotericin B, non-parenteral formulations, self-emulsifying drug delivery systems, opportunistic fungal infections, kidney toxicity.

Graphical Abstract
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