Abstract
Background: Gouty arthritis is a complex form of inflammatory arthritis, triggered by the sedimentation of monosodium urate crystals in periarticular tissues, synovial joints, and other sites in the body. Curcumin is a natural polyphenol compound, isolated from the rhizome of the plant Curcuma longa, possessing countless physiological features, including antioxidant, anti-inflammatory, and anti-rheumatic qualities.
Objective: This study aimed to discuss the beneficial impacts of curcumin and its mechanism in treating gout disease.
Methods: Ten English and Persian databases were used to conduct a thorough literature search. Studies examining the anti-gouty arthritis effects of curcumin and meeting the inclusion criteria were included.
Results: According to the studies, curcumin has shown xanthine oxidase and urate transporter- 1 inhibitory properties, uric acid inhibitory characteristics, and antioxidant and anti- inflammatory effects. However, some articles found no prominent reduction in uric acid levels.
Conclusion: In this review, we emphasized the potency of curcumin and its compounds against gouty arthritis. Despite the potency, we suggest an additional well-designed evaluation of curcumin, before its therapeutic effectiveness is completely approved as an antigouty arthritis agent.
Keywords: Arthritis, joint diseases, curcumin, gout, uric acid, Curcuma longa.
[http://dx.doi.org/10.1016/j.biopha.2020.110590]
[http://dx.doi.org/10.1189/jlb.3MA0915-418R] [PMID: 26868525]
[http://dx.doi.org/10.1002/art.27338] [PMID: 20131266]
[http://dx.doi.org/10.1016/j.metop.2021.100100] [PMID: 34189452]
[http://dx.doi.org/10.1016/j.molmed.2017.06.005.] [PMID: 28732688]
[http://dx.doi.org/10.1038/s41584-020-0441-1] [PMID: 32541923]
[http://dx.doi.org/10.2337/db12-1814] [PMID: 24065788]
[http://dx.doi.org/10.1038/srep39551] [PMID: 28000751]
[http://dx.doi.org/10.1016/j.intimp.2016.12.031.] [PMID: 28068647]
[http://dx.doi.org/10.1002/art.24185.] [PMID: 19116939]
[http://dx.doi.org/10.1038/nature04516] [PMID: 16407889]
[http://dx.doi.org/10.1097/RHU.0b013e31827d8790] [PMID: 23319019]
[PMID: 35980068]
[PMID: 24379904]
[PMID: 29629341]
[http://dx.doi.org/10.1002/jcp.26848] [PMID: 29968913]
[http://dx.doi.org/10.1016/j.cell.2007.08.024] [PMID: 17803897]
[http://dx.doi.org/10.1002/jcp.27442.] [PMID: 30317564]
[http://dx.doi.org/10.1016/j.neulet.2017.08.065]
[http://dx.doi.org/10.1186/ar3552] [PMID: 22225548]
[http://dx.doi.org/10.3949/ccjm.75.Suppl_5.S13] [PMID: 18822470]
[http://dx.doi.org/10.1080/15257770.2011.596496] [PMID: 22132951]
[http://dx.doi.org/10.1186/ar1906] [PMID: 16820040]
[http://dx.doi.org/10.1021/np8007123] [PMID: 19388706]
[http://dx.doi.org/10.1080/19390211.2020.1757798] [PMID: 32420786]
[http://dx.doi.org/10.1093/carcin/15.8.1717] [PMID: 8055654]
[http://dx.doi.org/10.1016/j.bmcl.2009.09.076] [PMID: 19800788]
[http://dx.doi.org/10.1016/j.bmc.2016.10.022] [PMID: 28340987]
[http://dx.doi.org/10.1016/S0378-8741(00)00305-6] [PMID: 11025157]
[http://dx.doi.org/10.1021/np970237h] [PMID: 9461655]
[http://dx.doi.org/10.1016/S0006-291X(02)00442-4] [PMID: 12054758]
[http://dx.doi.org/10.1080/14786410601129648] [PMID: 17365708]
[http://dx.doi.org/10.1016/j.jnutbio.2013.09.013] [PMID: 24445038]
[http://dx.doi.org/10.1097/FJC.0000000000000406] [PMID: 27124606]
[http://dx.doi.org/10.2174/1389450120666181122100511] [PMID: 30465499]
[http://dx.doi.org/10.1016/j.fitote.2011.12.028] [PMID: 22248534]
[http://dx.doi.org/10.1021/jm1015022] [PMID: 21449597]
[http://dx.doi.org/10.1038/sj.bjp.0702803] [PMID: 10510448]
[http://dx.doi.org/10.1007/s00011-009-0063-1] [PMID: 19579007]
[http://dx.doi.org/10.1016/S0167-4943(01)00194-7] [PMID: 14764309]
[http://dx.doi.org/10.1111/ijcp.14280] [PMID: 33914984]
[http://dx.doi.org/10.1089/107555303321223035] [PMID: 12676044]
[http://dx.doi.org/10.1016/j.intimp.2021.107375] [PMID: 33517224]
[http://dx.doi.org/10.1016/j.intimp.2019.105886] [PMID: 31520990]
[http://dx.doi.org/10.1002/art.41245] [PMID: 32134203]
[PMID: 30697988]
[http://dx.doi.org/10.1538/expanim.14-0027] [PMID: 25312506]
[http://dx.doi.org/10.1016/j.canlet.2019.02.035] [PMID: 30796968]
[http://dx.doi.org/10.18632/oncotarget.12918] [PMID: 27793052]
[http://dx.doi.org/10.3389/fimmu.2018.01427] [PMID: 29977244]
[http://dx.doi.org/10.1016/j.jacl.2020.07.003] [PMID: 32792218]
[http://dx.doi.org/10.1080/15548627.2017.1293766] [PMID: 28318352]
[http://dx.doi.org/10.3389/fphar.2015.00262] [PMID: 26594174]
[http://dx.doi.org/10.1016/j.lfs.2020.119005.]
[http://dx.doi.org/10.1016/j.cbi.2017.10.012] [PMID: 29031534]
[http://dx.doi.org/10.2174/1871529X18666180212114816.]
[http://dx.doi.org/10.1016/j.molimm.2018.09.004] [PMID: 30396035]
[http://dx.doi.org/10.1002/jcb.27969] [PMID: 30592318]
[http://dx.doi.org/10.1016/j.biopha.2019.109195] [PMID: 31362244]
[http://dx.doi.org/10.1186/s13075-019-1974-z] [PMID: 30606217]
[http://dx.doi.org/10.1155/2014/191624] [PMID: 25215173]
[http://dx.doi.org/10.1179/2045772313Y.0000000179] [PMID: 24621048]
[http://dx.doi.org/10.4049/jimmunol.1701495] [PMID: 29549176]
[http://dx.doi.org/10.1111/j.1600-065X.2011.01043.x] [PMID: 21884174]
[http://dx.doi.org/10.1016/S0092-8674(02)00703-1] [PMID: 11983155]
[http://dx.doi.org/10.1101/gad.1228704] [PMID: 15371334]
[http://dx.doi.org/10.1172/JCI11830] [PMID: 11134171]
[PMID: 12233891]
[http://dx.doi.org/10.1007/s00011-006-0067-z] [PMID: 16807698]
[http://dx.doi.org/10.1016/0378-8741(93)90005-P] [PMID: 8510458]
[http://dx.doi.org/10.1016/0262-1746(86)90146-0] [PMID: 3460103]
[http://dx.doi.org/10.1097/00024382-200301000-00017] [PMID: 12558151]
[http://dx.doi.org/10.1016/0006-2952(93)90476-D] [PMID: 8216378]
[http://dx.doi.org/10.2174/1573401316999200421095134]
[http://dx.doi.org/10.1016/j.immuni.2011.09.010] [PMID: 21982598]
[http://dx.doi.org/10.1016/j.phrs.2019.104351] [PMID: 31315067]
[http://dx.doi.org/10.3109/08820139.2016.1153651] [PMID: 27219123]
[http://dx.doi.org/10.1016/j.bbrc.2018.02.166] [PMID: 29476737]
[http://dx.doi.org/10.1136/rmdopen-2016-000284.] [PMID: 28243466]
[http://dx.doi.org/10.1007/s13238-011-1006-5.] [PMID: 21337007]
[http://dx.doi.org/10.1155/2019/8659302] [PMID: 31485194]
[http://dx.doi.org/10.1155/2017/3908061.] [PMID: 28316374]
[http://dx.doi.org/10.1371/journal.pone.0148082.] [PMID: 26890073]
[http://dx.doi.org/10.3390/antibiotics11030322] [PMID: 35326785]
[http://dx.doi.org/10.3390/pharmaceutics13122102] [PMID: 34959384]
[http://dx.doi.org/10.3390/medicina55010010] [PMID: 30642012]
[http://dx.doi.org/10.1021/nn2005574] [PMID: 21696187]
[http://dx.doi.org/10.4236/ojra.2013.32015]
[http://dx.doi.org/10.1016/j.intimp.2020.106842] [PMID: 32738598]
[PMID: 17014007]
[http://dx.doi.org/10.3390/ijms20133328] [PMID: 31284572]
[http://dx.doi.org/10.1111/nyas.12458] [PMID: 24840700]
[http://dx.doi.org/10.1007/s10067-020-05090-8] [PMID: 32382830]
[http://dx.doi.org/10.1038/s41584-019-0277-8] [PMID: 31515542]
[http://dx.doi.org/10.1111/imr.12621] [PMID: 29247995]
[http://dx.doi.org/10.1016/j.autrev.2020.102617] [PMID: 32663626]
[http://dx.doi.org/10.3389/fimmu.2019.01412] [PMID: 31281320]
[http://dx.doi.org/10.3390/ijms20030649] [PMID: 30717382]
[http://dx.doi.org/10.1111/imr.12616] [PMID: 29247988]
[http://dx.doi.org/10.3389/fimmu.2018.00763] [PMID: 29731751]
[http://dx.doi.org/10.1016/j.bbrc.2018.08.139] [PMID: 30166062]
[http://dx.doi.org/10.3346/jkms.2013.28.9.1289] [PMID: 24015032]
[http://dx.doi.org/10.1172/JCI28075] [PMID: 16886064]
[http://dx.doi.org/10.2337/dc08-1710] [PMID: 19092166]
[http://dx.doi.org/10.1016/j.semarthrit.2019.11.009]
[http://dx.doi.org/10.7150/thno.48028] [PMID: 33204337]
[http://dx.doi.org/10.1111/bph.14967] [PMID: 31883118]
[http://dx.doi.org/10.1016/j.freeradbiomed.2014.04.021] [PMID: 24780252]
[http://dx.doi.org/10.1002/art.38112] [PMID: 23918657]
[http://dx.doi.org/10.1126/science.1156995] [PMID: 18403674]
[http://dx.doi.org/10.1038/nature09663] [PMID: 21124315]
[http://dx.doi.org/10.3389/fimmu.2019.00070] [PMID: 30761138]
[http://dx.doi.org/10.3390/ijms22179221] [PMID: 34502127]
[http://dx.doi.org/10.1007/s00281-013-0361-0]
[http://dx.doi.org/10.1111/febs.16036] [PMID: 34042290]
[http://dx.doi.org/10.1002/ptr.4639] [PMID: 22407780]
[http://dx.doi.org/10.1007/s00776-014-0633-0] [PMID: 25308211]
[http://dx.doi.org/10.1016/j.ejps.2015.07.012] [PMID: 26206297]
[http://dx.doi.org/10.1002/ejp.620] [PMID: 25400173]
[http://dx.doi.org/10.1016/j.biomaterials.2013.05.055] [PMID: 23777916]
[http://dx.doi.org/10.1002/ptr.7190] [PMID: 34131980]
[http://dx.doi.org/10.3390/pharmaceutics14102239] [PMID: 36297677]
[http://dx.doi.org/10.1002/ptr.7656] [PMID: 36196887]
[http://dx.doi.org/10.3390/cells12040612]
[http://dx.doi.org/10.1016/j.burns.2022.06.016] [PMID: 35850880]
[http://dx.doi.org/10.3390/molecules28020742] [PMID: 36677800]
[http://dx.doi.org/10.1016/j.phrs.2020.104921.] [PMID: 32464325]