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Current Drug Discovery Technologies


ISSN (Print): 1570-1638
ISSN (Online): 1875-6220

Mini-Review Article

CBD: A Potential Lead against Hair Loss, Alopecia, and its Potential Mechanisms

Author(s): Pranay Wal* and Ankita Wal

Volume 21, Issue 2, 2024

Published on: 01 September, 2023

Article ID: e200723218949 Pages: 9

DOI: 10.2174/1570163820666230720153607

Price: $65


Background: Nowadays, the majority of the population suffers from the problem of hair loss. It leads to disturbed mental health, lower self-confidence, and a lot more problems. A lot of the hair loss therapies available are not reliable and lead to recurrence and side effects after some time. Cannabinoids (CBD) have recently become quite popular for their benefits against hair loss. CBD oil preparations have been used both internally and externally for oral and topical use, respectively. Due to the presence of the endocannabinoid system (ECS) in the body, which naturally targets CB1 and CB2 receptors, the control of hair fall is possible. CBD is used topically for hair loss, whereas it is administered orally for the treatment and management of a medical condition, i.e., alopecia.

Aim/Objective: The present review aimed to provide an in-depth study on hair loss and its management using CBD and its associated mechanisms.

Methods: Electronic databases, such as ScienceDirect, Google Scholar, PubMed, Wiley, Springer, and Scopus, were thoroughly searched for information about how CBD is used, how it works, and what role it plays in treating alopecia and hair loss.

Results: This review has highlighted the use of CBD-based hair loss therapy, and described various types of hair loss and their treatments. This review also details the phytocannabinoids and the potential mechanisms of CBD's activity against hair loss and alopecia.

Conclusion: The data obtained from the literature regarding CBD and hair loss provide a scientific basis for CBD use in alopecia. Additionally, a more precise and comprehensive study concerning CBD needs to be carried out at the pre-clinical and clinical levels.

Keywords: Endocannabinoid system, cannabinoids, alopecia, hair loss, mental health, anti-inflammatory, antioxidant.

Graphical Abstract
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