Anti Oxidant Property of New Cephalosporin-Aminoglycoside Fixed Dose Combination

Manu      Chaudhary; Arvind      Soni; Vivek   Kumar   Dwivedi; Rajesh      Sehgal

Abstract

Aminoglycosides are known to cause oxidative stress related toxicities and tissue injuries. Present study was planned to evaluate the effect of aminoglycosides on blood oxidative stress parameters in mice and free radical scavenging potential of cephalosporins, when combined as a single injection with aminoglycosides using chemical vector mediated technology. Mus musculus mice were divided into five groups: Control group animals (treated with normal saline), amikacin treated group, tobramycin treated group, cefepime + amikacin treated group and ceftazidime + tobramycin treated group. A significant improvement in superoxide dismutase (SOD), catalase activities, along with malonaldialdehyde (MDA) levels and creatinine levels were observed in fixed dose combination of cephalosporins and aminoglycosides treated groups as compared to aminoglycosides alone (amikacin and tobramycin) treated groups. These findings indicate that on combining cephalosporins with aminoglycosides using chemical vector mediated technology prevents oxidative stress related tissues injury induced by aminoglycosides.

Keywords: Cephalosporin, aminoglycoside, free radicals, catalase, superoxide dismutase, malonaldialdehyde

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