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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Epigenetic Effects of Psychoactive Drugs

Author(s): Rania Ahmed, Kenneth Blum and Panayotis K. Thanos*

Volume 29, Issue 27, 2023

Published on: 17 July, 2023

Page: [2124 - 2139] Pages: 16

DOI: 10.2174/1381612829666230706143026

Price: $65


Currently, and globally, we are facing the worst epidemic of psychoactive drug abuse resulting in the loss of hundreds of thousands of lives annually. Besides alcohol and opioid use and misuse, there has been an increase in illicit abuse of psychostimulants. Epigenetics is a relatively novel area of research that studies heritable alterations in gene expression. Long-term administration of psychoactive drugs may lead to transcriptional changes in brain regions related to drug-seeking behaviors and rewards that can be passed down transgenerationally. Epigenetic biomarkers such as DNA methylation and histone modifications contribute to disease diagnoses. This review aims to look at the epigenetic modifications brought forth by psychoactive drug abuse.

Keywords: Epigenetics, psychoactive drugs, epigenetic biomarkers, DNA methylation, transgenerational, histone modifications.

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