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Anti-Infective Agents in Medicinal Chemistry


ISSN (Print): 1871-5214
ISSN (Online): 1875-6018

Recent Developments in the Synthesis of Novel Aminoglycoside Antibiotics

Author(s): Jie Li and Cheng-Wei Tom Chang

Volume 5, Issue 3, 2006

Page: [255 - 271] Pages: 17

DOI: 10.2174/187152106777697844

Price: $65


Aminoglycosides represent an important resource against infectious diseases. However, the prevalence of aminoglycoside resistant bacteria has limited their clinical efficacy and prompted the renewed interest in the study of resistant mechanisms as well as the development of novel aminoglycoside antibiotics. This review will focus on the latest development in the design and synthesis of novel aminoglycoside derivatives.

Keywords: Tobramycin Derivatives, O-5 Glycosylated Neomycin, methicillin resistant S. aureus (MRSA), Conformational constrained neomycin, RNA targets, Kanamycin, glycosylation

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