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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Multi-vesicular Liposome and its Applications: A Novel Chemically Modified Approach for Drug Delivery Application

Author(s): Kajal Ghosal*, Ayan Pani, Totan Chowdhury, Abhijeet Kundu and Sabu Thomas

Volume 24, Issue 1, 2024

Published on: 03 August, 2023

Page: [26 - 38] Pages: 13

DOI: 10.2174/1389557523666230613162512

Price: $65


Background: This study aimed to elaborate on all the aspects of multivesicular liposomes, including structure, function, topology, etc. Liposomes are a unique drug delivery system, in which both hydrophilic and hydrophobic drug molecules can be incorporated. Particularly, multivesicular liposomes have more advantages than other liposomes because of their unique structure. This study provides an overview of several works already performed by various researchers in this field. Numerous studies have reported on preparing and evaluating multivesicular liposomes for drug delivery applications. This study summarizes the process of formulating multivesicular liposomes and their application in drug delivery systems and provides details about how to resolve the problem of limited solubility and stability of biomolecules, along with controlled drug release kinetics, with the possibility of loading various drugs. There is no doubt that multivesicular liposome opens new avenues to develop novel drug delivery system for achieving the desired functional performances and expanding the applications in the drug delivery area.

Keywords: Multivesicular liposome, novel drug delivery, applications, functional performance, biomolecule, drug solubility.

Graphical Abstract
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