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Current Aging Science

Editor-in-Chief

ISSN (Print): 1874-6098
ISSN (Online): 1874-6128

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Editorial

The Implication of Alu cDNA in the Pathogenesis of ARMD

Author(s): Ali Nouraeinejad*

Volume 16, Issue 3, 2023

Published on: 21 June, 2023

Page: [168 - 169] Pages: 2

DOI: 10.2174/1874609816666230530095410

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Abstract

Age-related macular degeneration (ARMD or AMD) is a progressive, sight-threatening disease. The pathogenesis of ARMD is complex, involving many factors, such as metabolic, functional, genetic, and environmental factors. Recently, long interspersed nuclear element-1 (L1)– mediated reverse transcription (RT) of Alu RNA into cytoplasmic Alu complementary DNA (cDNA) has been associated with retinal pigment epithelium (RPE) destruction. These findings provide a strong input for a new direction in the management of ARMD, as certain human immunodeficiency virus (HIV) drugs, such as nucleoside reverse transcriptase inhibitors (NRTIs), were found to suppress inflammation and protect cells of the retina.

Keywords: Age-related macular degeneration, Alu complementary DNA, inflammasome activation, retinal pigment epithelium, nucleoside reverse transcriptase inhibitors, HIV.

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