Abstract
Staphylococcus growth on medical devices represents a common occurrence that can lead to serious illness and death. Biomaterial-associated infection, mostly caused by Staphylococcus epidermidis and Staphylococcus aureus, is fairly complicated by the organismdevelopment of a biofilm, which provides a microenvironment that protects from attack by the host immune system and antibiotics. In this review we present recent insights regarding S. aureus and S. epidermidis structural and functional factors that are effective in biofilm development and describe the regulation of their expression. On the basis of the knowledge gained, we also present the potential and limits of current biochemical and biophysical strategies aimed at preventing biofilm formation or at the treatment of established mature biofilms.
Keywords: Staphylococcus, biofilm, biomaterials, therapeutic strategies
Current Medicinal Chemistry
Title: Prevention and Treatment of Staphylococcus Biofilms
Volume: 15 Issue: 30
Author(s): Pietro Speziale, Livia Visai, Simonetta Rindi, Giampiero Pietrocola, Giulio Provenza and Maria Provenzano
Affiliation:
Keywords: Staphylococcus, biofilm, biomaterials, therapeutic strategies
Abstract: Staphylococcus growth on medical devices represents a common occurrence that can lead to serious illness and death. Biomaterial-associated infection, mostly caused by Staphylococcus epidermidis and Staphylococcus aureus, is fairly complicated by the organismdevelopment of a biofilm, which provides a microenvironment that protects from attack by the host immune system and antibiotics. In this review we present recent insights regarding S. aureus and S. epidermidis structural and functional factors that are effective in biofilm development and describe the regulation of their expression. On the basis of the knowledge gained, we also present the potential and limits of current biochemical and biophysical strategies aimed at preventing biofilm formation or at the treatment of established mature biofilms.
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Cite this article as:
Speziale Pietro, Visai Livia, Rindi Simonetta, Pietrocola Giampiero, Provenza Giulio and Provenzano Maria, Prevention and Treatment of Staphylococcus Biofilms, Current Medicinal Chemistry 2008; 15 (30) . https://dx.doi.org/10.2174/092986708786848442
DOI https://dx.doi.org/10.2174/092986708786848442 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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