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Pharmaceutical Nanotechnology

Editor-in-Chief

ISSN (Print): 2211-7385
ISSN (Online): 2211-7393

Review Article

Targeted Approach to Enhance the Solubility of Weakly Soluble Drugs by Nanocrystal Technology

Author(s): Sangam Rana, Deepali Tomar*, Peeyush Kaushik, Prerna Sharma, Nidhi Rani* and Kumar Guarve

Volume 11, Issue 5, 2023

Published on: 08 June, 2023

Page: [425 - 432] Pages: 8

DOI: 10.2174/2211738511666230504115640

Price: $65

Abstract

About 90% of the newly discovered drugs are poorly soluble in water, to overcome this problem, nanocrystal technology is used. Nanocrystal technology is a modern technique that is specially used to increase the solubility of less soluble drugs. Production of a nanocrystal on a large scale can be done by techniques like homogenization (high-pressure), precipitation, and milling methods. Using this technique, saturation solubility, the adhesiveness of a drug molecule to the surface cell, and the dissolution velocity is enhanced. This technology is better than the traditional method because it provides certain other benefits like increased drug loading capability, fantastic reproducibility of oral retention, further developed proportionality of portion bioavailability and expanded patient compliance. This audit makes sense of the various kinds of techniques for the arrangement of nanocrystals, benefits, drawbacks, a system of solvency improvement, clinical applications, and future imminent. This review article also provides further guidelines for studies about nanocrystal technology.

Keywords: Nanocrystals, nanocrystal technology, homogenization, drug delivery, hydrophilic drugs, BCS.

Graphical Abstract
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