Genetics in Osteoarthritis

Title: Genetics in Osteoarthritis

Volume: 9 Issue: 8

Author(s): Mercedes Fernandez-Moreno, Ignacio Rego, Vanessa Carreira-Garcia and Francisco J. Blanco

Affiliation:

Keywords: Osteoarthritis, genetics, chondrocyte, cytokines

Abstract: Osteoarthritis is a degenerative articular disease with complex pathogeny because diverse factors interact causing a process of deterioration of the cartilage. Despite the multifactorial nature of this pathology, from the 50s its known that certain forms of osteoarthritis are related to a strong genetic component. The genetic bases of this disease do not follow the typical patterns of mendelian inheritance and probably they are related to alterations in multiple genes. The identification of a high number of candidate genes to confer susceptibility to the development of the osteoarthritis shows the complex nature of this disease. At the moment, the genetic mechanisms of this disease are not known, however, which seems clear is that expression levels of several genes are altered, and that the inheritance will become a substantial factor in future considerations of diagnosis and treatment of the osteoarthritis.

Cite this article as:

Fernandez-Moreno Mercedes, Rego Ignacio, Carreira-Garcia Vanessa and Blanco J. Francisco, Genetics in Osteoarthritis, Current Genomics 2008; 9 (8) . https://dx.doi.org/10.2174/138920208786847953