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Current Drug Safety


ISSN (Print): 1574-8863
ISSN (Online): 2212-3911

Case Report

Amoxicillin Induced Fever, Rash, and Catatonia - A Case Study

Author(s): Chunnu Kumar Yadav, Rajat Ranka, Prasan Kumar Panda*, Bishal Pratap Shah, Mayank Kumar Mishra and Vijay Krishnan

Volume 19, Issue 2, 2024

Published on: 05 April, 2023

Page: [282 - 285] Pages: 4

DOI: 10.2174/1574886318666230308094209

Price: $65


Introduction: Adverse drug reactions (ADR) are defined as any harmful or unpleasant events or injuries resulting from the use of any particular drug. Among those antibiotics that cause adverse reactions, amoxicillin is one of them. Catatonia and vasculitic rash are its rare adverse effects.

Case Presentation: A 23-year-old postpartum female, with a history of taking empirical Amoxiclav (amoxicillin-clavulanic acid 625 mg) injection and oral tablets for episiotomy wound, presented with altered sensorium and fever followed by maculopapular rash. On examination, she had generalized rigidity with waxy flexibility that improved by lorazepam challenge and was diagnosed as catatonia. On evaluation, amoxicillin was found to be precipitating catatonia in this patient.

Conclusion: Since the diagnosis of catatonia is often missed, any cases with clinical presentation of fever, rash, altered sensorium, and generalized rigidity should also be suspected for druginduced ADR and the precipitating factor should be searched for.

Keywords: Adverse drug reaction, amoxicillin-clavulanic acid, drug-induced catatonia, postpartum, vasculitic rash, fever.

Graphical Abstract
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