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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Recent Advances on the Antimicrobial Activities of Schiff Bases and their Metal Complexes: An Updated Overview

Author(s): Juliana Jorge, Kristiane Fanti Del Pino Santos, Fernanda Timóteo, Rafael Rodrigo Piva Vasconcelos, Osmar Ignacio Ayala Cáceres, Isis Juliane Arantes Granja, David Monteiro de Souza, Tiago Elias Allievi Frizon, Giancarlo Di Vaccari Botteselle, Antonio Luiz Braga, Sumbal Saba*, Haroon ur Rashid* and Jamal Rafique*

Volume 31, Issue 17, 2024

Published on: 03 May, 2023

Page: [2330 - 2344] Pages: 15

DOI: 10.2174/0929867330666230224092830

Price: $65


Schiff bases represent a valuable class of organic compounds, synthesized via condensation of primary amines with ketones or aldehydes. They are renowned for possessing innumerable applications in agricultural chemistry, organic synthesis, chemical and biological sensing, coating, polymer and resin industries, catalysis, coordination chemistry, and drug designing. Schiff bases contain imine or azomethine (-C=N-) functional groups which are important pharmacophores for the design and synthesis of lead bioactive compounds. In medicinal chemistry, Schiff bases have attracted immense attention due to their diverse biological activities. This review aims to encompass the recent developments on the antimicrobial activities of Schiff bases. The article summarizes the antibacterial, antifungal, antiviral, antimalarial, and antileishmanial activities of Schiff bases reported since 2011.

Keywords: Schiff base, antimicrobial activity, imine, azomethine, antibacterial, antifungal, antiviral, antimalarial.

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