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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Research Article

Percutaneous Coronary Intervention Associated with a Higher Risk of Hypoxemia and COVID-19 Severity

Author(s): Sepideh Karkon Shayan, Elham Nasrollahi, Yaser Bahramvand, Mahdi Zarei, Ahmadreza Atarodi, Yeganeh Farsi, Mitra Tavakolizadeh, Milad Shirvaliloo, Mitra Abbasifard, Tannaz Jamialahmadi, Maciej Banach and Amirhossein Sahebkar*

Volume 31, Issue 10, 2024

Published on: 05 April, 2023

Page: [1265 - 1277] Pages: 13

DOI: 10.2174/0929867330666230222104345

Price: $65


Objective: The primary goal of the present study was to measure the implications of hypoxemia in COVID-19 patients with a history of coronary artery disease (CAD).

Methods: A systematic search of the literature published from November 1, 2019 to May 1, 2021, was conducted on PubMed/MEDLINE, Embase, and Web of Science databases. Afterwards, an observational study was designed based on the electronic health records of COVID-19 patients hospitalized in a tertiary referral hospital during the same period. A total of 179 COVID-19 cases were divided into two groups: cases with a history of CAD and percutaneous coronary intervention (CAD/PCI+, n = 89) and controls (n = 90). Clinical data were extracted from the electronic database of the hospital and statistically analyzed.

Results: After the application of inclusion/exclusion criteria, only three studies were deemed eligible, one of which was concerned with the impact of CAD on the all-cause mortality of COVID-19. Results from our observational study indicated that the cases were older (median age: 74 vs. 45) and more likely to develop hypoxemia (25.8% vs. 8.8%) than the controls. CAD/PCI+ was correlated with a more severe COVID-19 (11% vs. 1%). Age was a moderately significant independent predictor of increased COVID-19 severity, while hypoxemia was not.

Conclusion: Considering the negative impact of hypoxemia on the prognosis of COVID-19 and its higher prevalence among COVID-19 patients with underlying CAD, further research is warranted to unravel the negative effects of COVID-19 on the mechanisms of gas exchange and delivery in patients with pre-existing CAD.

Keywords: Coronavirus disease 2019, COVID-19, percutaneous coronary intervention, angioplasty, hypoxemia, emerging infectious disease.

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