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Current Traditional Medicine


ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

Mini-Review Article

COVID-19: Impact, Diagnosis, Management and Phytoremediation

Author(s): Athar Ata*, Samina Naz, Simran Sandhu and Bilge Sener

Volume 9, Issue 6, 2023

Published on: 20 February, 2023

Article ID: e070223213500 Pages: 9

DOI: 10.2174/2215083809666230207142240

Price: $65


COVID-19, or SARS-CoV-2, is an extremely deadly virus that is responsible for over half a million deaths of people in the world. This virus originated in China in December 2019 and rapidly spread worldwide in 2-3 months, and affected every part of the world. Its life-threatening nature forced governments in all countries to take emergency steps of lockdown that affected the entire world's education, health, social and economic aspects. Due to the implementation of these emergencies, the population is facing psychological, social and financial problems. Additionally, this pandemic has significantly influenced the health care systems as all the resources from governments of all countries were directed to invest funds to discover new diagnostic tests and manage COVID-19 infection. The impact of the COVID-19 pandemic on the education and social life of the population is described in this article. Additionally, the diagnosis, management, and phytoremediation to control the spread of COVID-19 and traditional medicinal plants' role in managing its mild symptoms have been discussed.

Keywords: COVID-19, SARS-CoV-2, RT-PCR test, antiviral drugs, on-line education, phytoremediation, phytochemistry.

Rehman MF, Fariha C, Anwar A, et al. Novel coronavirus disease (COVID-19) pandemic: A recent mini review. Comput Struct Biotechnol J 2021; 19: 612-23.
[] [PMID: 33398233]
Remuzzi A, Remuzzi G. COVID-19 and Italy: what next? Lancet 2020; 395(10231): 1225-8.
[] [PMID: 32178769]
Bernard Stoecklin S, Rolland P, Silue Y, et al. First cases of coronavirus disease 2019 (COVID-19) in France: surveillance, investigations and control measures, January 2020. Euro Surveill 2020; 25(6): 2000094.
[] [PMID: 32070465]
WHO. Novel coronavirus situation dashboard. Geneva, Switzerland: WHO 2020.
Chaturvedi K, Vishwakarma DK, Singh N. COVID-19 and its impact on education, social life and mental health of students: A survey. Child Youth Serv Rev 2021; 121: 105866.
[] [PMID: 33390636]
Karlinsky A, Kobak D. Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset. eLife 2021; 10: e69336.
[] [PMID: 34190045]
Pascarella G, Strumia A, Piliego C, et al. COVID-19 diagnosis and management: a comprehensive review. J Intern Med 2020; 288(2): 192-206.
Saha J, Barman B, Chouhan P. Lockdown for COVID-19 and its impact on community mobility in India: An analysis of the COVID-19 Community Mobility Reports, 2020. Child Youth Serv Rev 2020; 116: 105160.
Grépin KA, Ho TL, Liu Z, et al. Evidence of the effectiveness of travel-related measures during the early phase of the COVID-19 pandemic: a rapid systematic review. BMJ Glob Health 2021; 6(3): e004537.
[] [PMID: 33722793]
WHO Statement on the second meeting of the International health regulations (2005) emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV). 2020. Available from:
Worsnop CZ. Concealing disease: Trade and travel barriers and the timeliness of outbreak reporting. Int Stud Perspect 2019; 20(4): 344-72.
UNWTO. UNWTO world tourism barometer. 2020.
Bao W. COVID-19 and online teaching in higher education: A case study of Peking University. Hum Behav Emerg Technol 2020; 2(2): 113-5.
[] [PMID: 32510042]
Kapasia N, Paul P, Roy A, et al. Impact of lockdown on learning status of undergraduate and postgraduate students during COVID-19 pandemic in West Bengal, India. Child Youth Serv Rev 2020; 116: 105194.
[] [PMID: 32834270]
Madhusoodanan J. The pandemic’s slowing of research productivity may last years-especially for women and parents. Science 2021; 374(6567): 550-1.
Pokhrel S, Chhetri R. A Literature review on impact of COVID-19 pandemic on teaching and learning. Higher education for the future 2021; 8(1): 133-41.
Doucet A, Netolicky D, Timmers K, Tuscano FJ. Thinking about pedagogy in an unfolding pandemic (An Independent Report on Approaches to Distance Learning during COVID-19 School Closure). Work Edu Inter UNESCO 2020; p. 6. []
Basilaia G, Kvavadze D. Transition to online education in schools during a SARS-CoV-2 coronavirus (COVID-19) pandemic in Georgia. Pedagogical Res 2020; 2020: 10.
Arora VM, Wray CM, O’Glasser AY, Shapiro M, Jain S. Using the curriculum vitae to promote gender equity during the COVID-19 pandemic. Proc Natl Acad Sci 2020; 117(39): 24032-.
[] [PMID: 32943540]
Balasubramani J, Anbalagan M. Research productivity on COVID-19 in Dimension database: An analytical study. J Emerg Manag 2021; 18: 63-9.
Comas-Forgas R, Lancaster T, Calvo-Sastre A, Sureda-Negre J. Exam cheating and academic integrity breaches during the COVID-19 pandemic: An analysis of internet search activity in Spain. Heliyon 2021; 7(10): e08233.
[] [PMID: 34722942]
Baran L, Jonason PK. Academic dishonesty among university students: The roles of the psychopathy, motivation, and self-efficacy. PLoS One 2020; 15(8): e0238141.
[] [PMID: 32866171]
Prado-Román C, Gómez-Martínez R, Orden-Cruz C. Google trends as a predictor of presidential elections: the United States versus Canada. Am Behav Sci 2020; 65(4): 666-80.
Shakeel A, Shazli T, Salman MS, Naqvi HR, Ahmad N, Ali N. Challenges of unrestricted assignment-based examinations (ABE) and restricted open-book examinations (OBE) during COVID-19 pandemic in India: An experimental comparison. Hum Behav Emerg Technol 2021; 3(5): 1050-66.
[] [PMID: 34901770]
Xie X, Siau K, Nah FFH. COVID-19 pandemic – online education in the new normal and the next normal. J Info Technol Case App Res 2020; 22(3): 175-87.
Tamrat W, Dmatew T. COVID-19 poses a serious threat to higher education. Africa University World News 2020. Available from:,to%20move%20their%20courses%20online
Xu T. Psychological distress of international students during the COVID-19 pandemic in china: multidimensional effects of external environment, individuals’ behavior, and their values. Int J Environ Res Public Health 2021; 18(18): 9758.
[] [PMID: 34574677]
Chatterji P, Li Y. Effects of COVID-19 on school enrollment. Econ Educ Rev 2021; 83: 102128.
[] [PMID: 34720328]
Guidance Note on Education Systems’ Response to COVID-19. Google Scholar 2020; 6
Lee J. Mental health effects of school closures during COVID-19. Lancet Child Adolesc Health 2020; 4(6): 421.
[] [PMID: 32302537]
Valeria S, Davide A, Vincenzo A. The psychological and social impact of COVID-19: New perspectives of well-being. Front Psychol 2020; 2020: 11.
Brooks SK, Webster RK, Smith LE, et al. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet 2020; 395(10227): 912-20.
[] [PMID: 32112714]
Treccani. Einfuhlung. Tratto da Treccani, 2020. Available from: http://www. (Accessed on: 10 Feb 2022).
Monaghesh E, Hajizadeh A. The role of telehealth during COVID-19 outbreak: a systematic review based on current evidence. BMC Public Health 2020; 20(1): 1193.
[] [PMID: 32738884]
He F, Deng Y, Li W. Coronavirus disease 2019: What we know? J Med Virol 2020; 92(7): 719-25.
[] [PMID: 32170865]
WHO. Laboratory testing for 2019 novel coronavirus (2019- nCoV) in suspected human cases. In: Interim Guid. Geneva, Switzerland: World Health Organization site 2020.
Zou L, Ruan F, Huang M, et al. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med 2020; 382(12): 1177-9.
[] [PMID: 32074444]
Zhang W, Du RH, Li B, et al. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. Emerg Microbes Infect 2020; 9(1): 386-9.
[] [PMID: 32065057]
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395(10223): 497-506.
[] [PMID: 31986264]
Young BE, Ong SWX, Kalimuddin S, et al. Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore. JAMA 2020; 323(15): 1488-94.
[] [PMID: 32125362]
Zhang Y, Chen C, Zhu S, et al. Isolation of 2019-nCoV from a stool specimen of a laboratory-confirmed case of the coronavirus disease 2019 (COVID-19). China CDC Weekly 2020; 2(8): 123-4.
[] [PMID: 34594837]
Memish ZA, Assiri AM, Al-Tawfiq JA. Middle East respiratory syndrome coronavirus (MERS-CoV) viral shedding in the respiratory tract: an observational analysis with infection control implications. Int J Infect Dis 2014; 29: 307-8.
[] [PMID: 25448335]
Infantino M, Damiani A, Gobbi FL, et al. Serological assays for SARS-CoV-2 infectious disease: benefits, limitations and perspectives. Isr Med Assoc J 2020; 22(4): 203-10.
[PMID: 32286019]
Al Johani S, Hajeer AH. MERS-CoV diagnosis: An update. J Infect Public Health 2016; 9(3): 216-9.
[] [PMID: 27106390]
Zhao J, Yuan Q, Wang H, et al. Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019. Clin Infect Dis 2020; 71(16): 2027-34.
[] [PMID: 32221519]
Okba NMA, Muller MA, Li W, et al. SARS-CoV-2 specific antibody responses in COVID-19 patients. Emerg Infect Dis 2020; 26: 1478-88.
[] [PMID: 32267220]
Gorse GJ, Donovan MM, Patel GB. Antibodies to coronaviruses are higher in older compared with younger adults and binding antibodies are more sensitive than neutralizing antibodies in identifying coronavirus-associated illnesses. J Med Virol 2020; 92(5): 512-7.
[] [PMID: 32073157]
Kelly-Cirino C, Mazzola LT, Chua A, Oxenford CJ, Van Kerkhove MD. An updated roadmap for MERS-CoV research and product development: focus on diagnostics. BMJ Glob Health 2019; 4(S2): e001105.
[] [PMID: 30815285]
Amanat F, Stadlbauer D, Strohmeier S, et al. A serological assay to detect SARS-CoV-2 seroconversion in humans. Nat Med 2020; 26(7): 1033-6.
[] [PMID: 32398876]
Deeks JJ, Dinnes J, Takwoingi Y, et al. Antibody tests for identification of current and past infection with SARS-CoV-2. Cochrane Libr 2020; 2020(6): CD013652.
[] [PMID: 32584464]
Charlton CL, Kanji JN, Johal K, et al. Evaluation of six commercial mid to high volume antibody and six point of care lateral flow assays for detection of SARS-CoV-2 antibodies. J Clin Microbiol 2020; 58(10): e01361-20.
[] [PMID: 32665420]
Patel R, Babady E, Theel ES, et al. Report from the American Society for Microbiology COVID-19 International Summit, 23 March 2020: Value of Diagnostic Testing for SARS-CoV-2/COVID-19. MBio 2020; 11(2): e007722.
[] [PMID: 32217609]
FDA. Coronavirus Disease 2019 (COVID-19) Emergency use authorizations for medical devices. 2019. Available from: []
WHO. Laboratory testing strategy recommendations for COVID-19: interim guidance 20, 2020 2020. Available from: []
Centers for Disease Control and Prevention (CDC). Serology testing for COVID-19 at CDC. 2020. Available from: [ 019-ncov/lab/serology-testing.html]
Zayed RA, Omran D, Zayed AA. COVID-19 clinical and laboratory diagnosis overview. J Egypt Public Health Assoc 2021; 96(1): 25.
[] [PMID: 34406520]
Fan E, Del Sorbo L, Goligher EC, et al. An official American thoracic society/European Society of intensive care medicine/society of critical care medicine clinical practice guideline: Mechanical ventilation in adult patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 2017; 195(9): 1253-63.
[] [PMID: 28459336]
Aleissa MM, Silverman EA, Paredes Acosta LM, Nutt CT, Richterman A, Marty FM. New Perspectives on Antimicrobial Agents: Remdesivir Treatment for COVID-19. Antimicrob Agents Chemother 2020; 65(1): e01814-20.
[] [PMID: 33139290]
Villamagna AH, Gore SJ, Lewis JS, Doggett JS. The Need for Antiviral Drugs for Pandemic Coronaviruses From a Global Health Perspective. Front Med 2020; 7: 596587.
[] [PMID: 33415116]
Eastman RT, Roth JS, Brimacombe KR, et al. Remdesivir: a review of its discovery and development leading to emergency use authorization for treatment of COVID-19. ACS Cent Sci 2020; 6(5): 672-83.
[] [PMID: 32483554]
Zhang L, Liu Y. Potential interventions for novel coronavirus in China: A systematic review. J Med Virol 2020; 92(5): 479-90.
[] [PMID: 32052466]
Liver SE, Wallace M, See I, et al. Use of the janssen (Johnson & Johnson) COVID-19 vaccine: Updated interim recommendations from the advisory committee on immunization practices – United States, December 2021. Expert Rev Vaccines 2021; 71(3): 90-5.
Chapin-Bardales J. Reactogenicity following receipt of mRNA-based COVID-19 vaccinesexternal icon. JAMA Insights 2021; 70(27): 977-82.
Boopathi S, Poma AB, Kolandaivel P. Novel 2019 coronavirus structure, mechanism of action, antiviral drug promises and rule out against its treatment. J Biomol Struct Dyn 2020; 3409-18.
Fathizadeh H, Maroufi P, Momen-Heravi M, et al. Protection and disinfection policies against SARS-CoV-2 (COVID-19). Infez Med 2020; 28(2): 185-91.
[PMID: 32275260]
Santarpia JL, Rivera DN, Herrera V, et al. Transmission potential of SARS-CoV-2 in viral shedding observed at the University of Nebraska Medical Center. Sci Rep 2020; 2020: 1-12.
Lee BXY, Hadibarata T, Yuniarto A. Phytoremediation mechanisms in air pollution control: A review. Water Air Soil Pollut 2020; 231(8): 437.
Lee JH. An overview of phytoremediation as a potentially promising technology for environmental pollution control. Biotechnol Bioprocess Eng; BBE 2013; 18(3): 431-9.
Pegas PN, Alves CA, Nunes T, Bate-Epey EF, Evtyugina M, Pio CA. Could houseplants improve indoor air quality in schools? J Toxicol Environ Health A 2012; 75(22-23): 1371-80.
[] [PMID: 23095155]
Parseh I, Teiri H, Hajizadeh Y, Ebrahimpour K. Phytoremediation of benzene vapors from indoor air by schefflera arboricola and spathiphyllum wallisii plants. Atmos Pollut Res 9: 1083-7.
Abbass OA, Sailor DJ, Gall ET. Effectiveness of indoor plants for passive removal of indoor ozone. Build Environ 2017; 119: 62-70.
Fan G, Xie J, Yang H, Liu J. Improving indoor air humidity in heated rooms based on natural evaporation of water from wetted textile fabric - A pilot study. Procedia Eng 2017; 205: 1302-9.
Audi A, AlIbrahim M, Kaddoura M, Hijazi G, Yassine HM, Zaraket H. Seasonality of respiratory viral infections: Will COVID-19 follow suit? Front Public Health 2020; 8: 567184.
[] [PMID: 33042956]
Jeong SJ, Song JS, Kim WS, et al. evaluation of selected foliage plants for improvement of indoor humidity. Hortic Environ Biotechnol 2008; 49: 439-46.
Pérez-Urrestarazu L, Fernández-Cañero R, Franco A, Egea G. Influence of an active living wall on indoor temperature and humidity conditions. Ecol Eng 2016; 90: 120-4.
Lohr VI, Pearson-mims CH. Particulate matter accumulation on horizontal surfaces in interiors: Influence of foliage plants. Atmos Environ 1996; 30(14): 2565-8.
Limm EB, Simonin KA, Bothman AG, Dawson TE. Foliar water uptake: a common water acquisition strategy for plants of the redwood forest. Oecologia 2009; 161(3): 449-59.
[] [PMID: 19585154]
Gawrońska H, Bakera B. Phytoremediation of particulate matter from indoor air by Chlorophytum comosum L. plants. Air Qual Atmos Health 2015; 8(3): 265-72.
[] [PMID: 26052368]
Mushtaq W, Siddiqui MB, Rehman Hakeem K. Allelopathy Potential for Green Agriculture. New York, NY: Springer 2019; Vol. I.
Nazarenko Y. Air filtration and SARS-CoV-2. Epidemiol Health 2020; 42: e2020049.
[] [PMID: 32660218]
Yang H, Koo TH, Hong CY, et al. Analysis of the effects of essential oils on airborne bacteria in a customized bio-clean room. Mol Med Rep 2012; 6(3): 651-6.
[] [PMID: 22751732]
Key Things to Know Abouth COVID-19 Vaccines. 2021. Available from: know.html
Li Y, Liu X, Guo L, et al. Traditional Chinese herbal medicine for treating novel coronavirus (COVID-19) pneumonia: protocol for a systematic review and meta-analysis. Syst Rev 2020; 9(1): 75.
[] [PMID: 32268923]
Rastogi S, Pandey DN, Singh RH. COVID-19 pandemic: a pragmatic plan for ayurveda intervention. J Ayurveda Integr Med 2020; 20: 9475-6.
Tan TYC, Lee JC, Mohd Yusof NA, Teh BP, Syed Mohamed AF. Malaysian herbal monograph development and challenges. J Herb Med 2020; 23: 100380.
Yi LM, Ping TB, Chin TTY. Medicinal plants in COVID-19: Potential and limitations. Front Pharmacol 2021; 12.
Phumthum M, Varangrat N, Henrik B. Medicinal plants used for treating mild COVID-19 symptoms among thai karen and hmong. Front Pharmacol 2021; 12: 699897.
Galea S, Merchant RM, Lurie N. The mental health consequences of COVID-19 and physical distancing: the need for prevention and early intervention. JAMA Intern Med 2020; 180(6): 817-8.
[] [PMID: 32275292]
Kato TA, Sartorius N, Shinfuku N. Forced social isolation due to COVID-19 and consequent mental health problems: Lessons from hikikomori. Psychiatry Clin Neurosci 2020; 74(9): 506-7.
[] [PMID: 32654336]

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