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Anti-Cancer Agents in Medicinal Chemistry


ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Review Article

Glioblastoma as a Novel Drug Repositioning Target: Updated State

Author(s): Hamed Hosseinalizadeh, Ammar Ebrahimi, Ahmad Tavakoli and Seyed Hamidreza Monavari*

Volume 23, Issue 11, 2023

Published on: 03 March, 2023

Page: [1253 - 1264] Pages: 12

DOI: 10.2174/1871520623666230202163112

Price: $65


Glioblastoma multiforme (GBM) is an aggressive form of adult brain tumor that can arise from a low-grade astrocytoma. In recent decades, several new conventional therapies have been developed that have significantly improved the prognosis of patients with GBM. Nevertheless, most patients have a limited long-term response to these treatments and survive < 1 year. Therefore, innovative anti-cancer drugs that can be rapidly approved for patient use are urgently needed. One way to achieve accelerated approval is drug repositioning, extending the use of existing drugs for new therapeutic purposes, as it takes less time to validate their biological activity as well as their safety in preclinical models. In this review, a comprehensive analysis of the literature search was performed to list drugs with antiviral, antiparasitic, and antidepressant properties that may be effective in GBM and their putative anti-tumor mechanisms in GBM cells.

Keywords: Glioblastoma, drug repositioning, blood-brain barrier, non-cancer drugs, GBM, brain tumor.

Graphical Abstract
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