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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

The Use of the Inhibitory Receptors for Modulating the Immune Responses

Author(s): S. M. Henson, R. Macaulay, S. Kiani-Alikhan and A. N. Akbar

Volume 14 , Issue 26 , 2008

Page: [2643 - 2650] Pages: 8

DOI: 10.2174/138161208786264124

Price: $65


Inhibitory receptors of the CD28 family, CTLA-4 and PD-1 deliver negative signals that regulate the balance between T cell activation, tolerance, and immunopathology. Manipulation of these pathways has been utilized by pathogens and tumors to establish chronic infections or to promote tumor survival. In this review, we examine the role of CTLA-4 and PD-1 in regulating immune response and discuss their therapeutic potential during aging.

Keywords: Inhibitory, T cell, CTLA-4, PD-1

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